Flurazepam hydrochloride Solid powder Others Flurazepam Hydrochloride is the hydrochloride salt form of flurazepam, a member of the benzodiazepines and a long-acting depressor of the central nervous system (CNS) with sedative and hypnotic effects. Flurazepam binds to a specific site on the benzodiazepine-gamma-aminobutyric acid (GABA)-A-chloride ionophore receptor complex located on the neuronal membrane. Binding causes an allosteric modification of the receptor thereby enhancing the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events, which leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential, and a decrease in neuronal excitability. By modulating binding of the GABA inhibitory neurotransmitter to GABA-A receptors in the ascending reticular activating system, flurazepam blocks arousal of the cortical and limbic system, thereby exerting its sedative and hypnotic effect.
Flurazepam hydrochloride is a benzodiazepine.
Dalmane is a DEA Schedule IV controlled substance. Substances in the DEA Schedule IV have a low potential for abuse relative to substances in Schedule III.
460.8 g/mol
$ $99 In stock
Formulation: 460.8 g/mol
Source:
Usage:
Flurazepam hydrochloride - 1172-18-5

Flurazepam hydrochloride

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog Number: BT-268425

CAS Number: 1172-18-5

Molecular Formula: C21H25Cl3FN3O

Molecular Weight: 460.8 g/mol

CAS Number 1172-18-5
Product Name Flurazepam hydrochloride
Molecular Formula C21H25Cl3FN3O
Molecular Weight 460.8 g/mol
Appearance Solid powder
InChI InChI=1S/C21H23ClFN3O.2ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;;/h5-10,13H,3-4,11-12,14H2,1-2H3;2*1H
InChI Key ZIIJJOPLRSCQNX-UHFFFAOYSA-N
IUPAC Name 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one;dihydrochloride
Canonical SMILES CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F.Cl.Cl
Description Flurazepam Hydrochloride is the hydrochloride salt form of flurazepam, a member of the benzodiazepines and a long-acting depressor of the central nervous system (CNS) with sedative and hypnotic effects. Flurazepam binds to a specific site on the benzodiazepine-gamma-aminobutyric acid (GABA)-A-chloride ionophore receptor complex located on the neuronal membrane. Binding causes an allosteric modification of the receptor thereby enhancing the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events, which leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential, and a decrease in neuronal excitability. By modulating binding of the GABA inhibitory neurotransmitter to GABA-A receptors in the ascending reticular activating system, flurazepam blocks arousal of the cortical and limbic system, thereby exerting its sedative and hypnotic effect.
Flurazepam hydrochloride is a benzodiazepine.
Dalmane is a DEA Schedule IV controlled substance. Substances in the DEA Schedule IV have a low potential for abuse relative to substances in Schedule III.
Melting Point 406 to 424 °F (decomposes) (NTP, 1992)
Other CAS Number 1172-18-5
Physical Description Flurazepam dihydrochloride is an odorless off-white to yellow crystalline powder. (NTP, 1992)
Pictograms Irritant;Health Hazard
Related CAS 17617-23-1 (Parent)
Shelf Life >3 years if stored properly
SMILES CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F.Cl.Cl
Solubility greater than or equal to 100 mg/mL at 66° F (NTP, 1992)
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Synonyms Apo Flurazepam
Apo-Flurazepam
Dalmadorm
Dalmane
Dihydrochloride, Flurazepam
Dormodor
Flurazepam
Flurazepam Dihydrochloride
Flurazepam Hydrochloride
Flurazepam Mono Perchlorate
Flurazepam Mono-Perchlorate
Flurazepam Monohydrochloride
Hydrochloride, Flurazepam
Mono-Perchlorate, Flurazepam
Monohydrochloride, Flurazepam
Staurodorm
Reference 1: Jatczak-Śliwa M, Terejko K, Brodzki M, Michałowski MA, Czyzewska MM, Nowicka JM, Andrzejczak A, Srinivasan R, Mozrzymas JW. Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABA(A) Receptor Activity. Front Cell Neurosci. 2018 Aug 28;12:237. doi: 10.3389/fncel.2018.00237. eCollection 2018. PubMed PMID: 30210295; PubMed Central PMCID: PMC6121034. 2: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK501727/ PubMed PMID: 30000786. 3: Gul W, Gul SW, Stamper B, Godfrey M, ElSohly MA. LC-MS-MS Method Development and Analysis of Stimulants, Opiates, Synthetic Opiates, PCP, and Benzodiazepines in Wastewater. Preponderance of these Drugs During Football Games. Methods Mol Biol. 2018;1810:149-182. doi: 10.1007/978-1-4939-8579-1_15. PubMed PMID: 29974427. 4: Piergiovanni M, Cappiello A, Famiglini G, Termopoli V, Palma P. Determination of benzodiazepines in beverages using green extraction methods and capillary HPLC-UV detection. J Pharm Biomed Anal. 2018 May 30;154:492-500. doi: 10.1016/j.jpba.2018.03.030. Epub 2018 Mar 17. PubMed PMID: 29605792. 5: De Boeck M, Dehaen W, Tytgat J, Cuypers E. Ionic Liquid-Based Liquid-Liquid Microextraction for Benzodiazepine Analysis in Postmortem Blood Samples. J Forensic Sci. 2018 Mar 24. doi: 10.1111/1556-4029.13778. [Epub ahead of print] PubMed PMID: 29573426. 6: Carter LJ, Williams M, Martin S, Kamaludeen SPB, Kookana RS. Sorption, plant uptake and metabolism of benzodiazepines. Sci Total Environ. 2018 Jul 1;628-629:18-25. doi: 10.1016/j.scitotenv.2018.01.337. Epub 2018 Feb 13. PubMed PMID: 29428856. 7: Tang VM, Pasricha AN, Blumberger DM, Voineskos D, Pasricha S, Mulsant BH, Daskalakis ZJ. Should Benzodiazepines and Anticonvulsants Be Used During Electroconvulsive Therapy?: A Case Study and Literature Review. J ECT. 2017 Dec;33(4):237-242. doi: 10.1097/YCT.0000000000000441. Review. PubMed PMID: 28767528. 8: da Silveira Petruci JF, Liebetanz MG, Cardoso AA, Hauser PC. Absorbance detector for high performance liquid chromatography based on a deep-UV light-emitting diode at 235nm. J Chromatogr A. 2017 Aug 25;1512:143-146. doi: 10.1016/j.chroma.2017.07.029. Epub 2017 Jul 11. PubMed PMID: 28720223. 9: De Boeck M, Missotten S, Dehaen W, Tytgat J, Cuypers E. Development and validation of a fast ionic liquid-based dispersive liquid-liquid microextraction procedure combined with LC-MS/MS analysis for the quantification of benzodiazepines and benzodiazepine-like hypnotics in whole blood. Forensic Sci Int. 2017 May;274:44-54. doi: 10.1016/j.forsciint.2016.12.026. Epub 2016 Dec 26. PubMed PMID: 28094153. 10: Almoznino G, Haviv Y, Sharav Y, Benoliel R. An update of management of insomnia in patients with chronic orofacial pain. Oral Dis. 2017 Nov;23(8):1043-1051. doi: 10.1111/odi.12637. Epub 2017 Feb 22. Review. PubMed PMID: 28075519. 11: Stamper B, Gul W, Godfrey M, Gul SW, ElSohly MA. LC-MS-MS Method for Analysis of Benzodiazepines in Wastewater During Football Games IV. J Anal Toxicol. 2017 Apr 1;41(3):205-213. doi: 10.1093/jat/bkw122. PubMed PMID: 27979928. 12: Ferrari A, Licata M, Rustichelli C, Baraldi C, Vandelli D, Marchesi F, Palazzoli F, Verri P, Silingardi E. Monitoring of adherence to headache treatments by means of hair analysis. Eur J Clin Pharmacol. 2017 Feb;73(2):197-203. doi: 10.1007/s00228-016-2163-5. Epub 2016 Nov 20. PubMed PMID: 27866243; PubMed Central PMCID: PMC5226977. 13: Schroeck JL, Ford J, Conway EL, Kurtzhalts KE, Gee ME, Vollmer KA, Mergenhagen KA. Review of Safety and Efficacy of Sleep Medicines in Older Adults. Clin Ther. 2016 Nov;38(11):2340-2372. doi: 10.1016/j.clinthera.2016.09.010. Epub 2016 Oct 15. Review. PubMed PMID: 27751669. 14: Bazmi E, Behnoush B, Akhgari M, Bahmanabadi L. Quantitative analysis of benzodiazepines in vitreous humor by high-performance liquid chromatography. SAGE Open Med. 2016 Sep 1;4:2050312116666243. doi: 10.1177/2050312116666243. eCollection 2016. PubMed PMID: 27635251; PubMed Central PMCID: PMC5011391. 15: Rudisill TM, Zhu M, Kelley GA, Pilkerton C, Rudisill BR. Medication use and the risk of motor vehicle collisions among licensed drivers: A systematic review. Accid Anal Prev. 2016 Nov;96:255-270. doi: 10.1016/j.aap.2016.08.001. Epub 2016 Aug 29. Review. PubMed PMID: 27569655; PubMed Central PMCID: PMC5045819. 16: Mata DC. Stability of 26 Sedative Hypnotics in Six Toxicological Matrices at Different Storage Conditions. J Anal Toxicol. 2016 Oct;40(8):663-668. Epub 2016 Aug 22. PubMed PMID: 27550995. 17: Maldifassi MC, Baur R, Sigel E. Molecular mode of action of CGS 9895 at α1 β2 γ2 GABAA receptors. J Neurochem. 2016 Sep;138(5):722-30. doi: 10.1111/jnc.13711. Epub 2016 Jul 18. PubMed PMID: 27319298. 18: Brodzki M, Rutkowski R, Jatczak M, Kisiel M, Czyzewska MM, Mozrzymas JW. Comparison of kinetic and pharmacological profiles of recombinant α1γ2L and α1β2γ2L GABAA receptors - A clue to the role of intersubunit interactions. Eur J Pharmacol. 2016 Aug 5;784:81-9. doi: 10.1016/j.ejphar.2016.05.015. Epub 2016 May 11. PubMed PMID: 27179992. 19: Kumar A, Chanana P, Choudhary S. Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs. Pharmacol Rep. 2016 Apr;68(2):231-42. doi: 10.1016/j.pharep.2015.09.002. Epub 2015 Sep 28. Review. PubMed PMID: 26922522. 20: Perez ER, Knapp JA, Horn CK, Stillman SL, Evans JE, Arfsten DP. Comparison of LC-MS-MS and GC-MS Analysis of Benzodiazepine Compounds Included in the Drug Demand Reduction Urinalysis Program. J Anal Toxicol. 2016 Apr;40(3):201-7. doi: 10.1093/jat/bkv140. Epub 2016 Jan 10. PubMed PMID: 26755538; PubMed Central PMCID: PMC4885916.
PubChem Compound Flurazepam hydrochloride
Last Modified Mar 14 2022