Ferric maltol
Catalog Number: BT-268511
CAS Number: 33725-54-1
Molecular Formula: C18H15FeO9
Molecular Weight: 431.2 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
Product Introduction
Description
Ferric maltol is a novel iron chelator that has gained significant attention in recent years due to its potential therapeutic and environmental applications. It is a complex of ferric iron and maltol, a natural compound found in many foods. Ferric maltol has been shown to have high bioavailability and low toxicity, making it an attractive candidate for various applications.
Properties
CAS Number
33725-54-1
Product Name
Ferric maltol
IUPAC Name
iron(3+);2-methyl-4-oxopyran-3-olate
Molecular Formula
C18H15FeO9
Molecular Weight
431.2 g/mol
InChI
InChI=1S/3C6H6O3.Fe/c3*1-4-6(8)5(7)2-3-9-4;/h3*2-3,8H,1H3;/q;;;+3/p-3
InChI Key
AHPWLYJHTFAWKI-UHFFFAOYSA-K
SMILES
CC1=C(C(=O)C=CO1)[O-].CC1=C(C(=O)C=CO1)[O-].CC1=C(C(=O)C=CO1)[O-].[Fe+3]
Solubility
Soluble in DMSO
Synonyms
Ferric maltol; Iron (III) maltol; ST10; ST-10; ST 10; ST10-021; ST-10-021; ST 10-021; ST10021; ST-10021; ST 10021; WHO 9974; WHO-9974; WHO9974;
Canonical SMILES
CC1=C(C(=O)C=CO1)[O-].CC1=C(C(=O)C=CO1)[O-].CC1=C(C(=O)C=CO1)[O-].[Fe+3]
Method of Synthesis or Extraction
Ferric maltol can be synthesized by reacting ferric chloride with maltol in the presence of a base. The reaction yields a complex of ferric iron and maltol, which can be purified by various methods such as precipitation, filtration, and chromatography. The efficiency and yield of the synthesis process depend on the reaction conditions, such as the concentration of reactants, pH, and temperature. The environmental and safety considerations of the synthesis process include the use of hazardous chemicals, waste disposal, and energy consumption.
Chemical Structure and Biological Activity
The chemical structure of ferric maltol consists of a central ferric ion coordinated with three maltol ligands. The complex has a high stability constant and a redox potential that allows it to bind to iron in biological systems. Ferric maltol has been shown to have potent iron-chelating activity, which makes it useful in treating iron overload disorders such as thalassemia and hemochromatosis. It also has anti-inflammatory and antioxidant properties, which may contribute to its therapeutic effects.
Biological Effects
Ferric maltol has been shown to affect cell function and signal transduction by regulating iron homeostasis and oxidative stress. It can modulate the expression of genes involved in iron metabolism, inflammation, and apoptosis. Ferric maltol has been tested in various preclinical and clinical studies for its potential therapeutic and toxic effects. It has been shown to be effective in reducing iron overload and improving anemia in patients with thalassemia. However, it may cause adverse effects such as gastrointestinal disturbances, liver toxicity, and hypersensitivity reactions.
Applications
Ferric maltol has various applications in medical, environmental, and industrial research. In medical research, it has been used as a potential drug candidate for treating iron overload disorders and other diseases associated with oxidative stress. It has been tested in clinical trials and found to be safe and effective in improving iron status and reducing iron-related complications. In environmental research, ferric maltol has been studied for its effects on ecosystems and its potential role in pollution management. It has been shown to have a low environmental impact and can be used as a sustainable alternative to other iron chelators. In industrial research, ferric maltol has been used in manufacturing processes to improve product quality and efficiency. It has also been studied for its health and safety considerations in the workplace.
Future Perspectives and Challenges
Despite the promising applications of ferric maltol, there are still limitations in its use and study. One of the challenges is the lack of long-term safety data and the potential for adverse effects. Another challenge is the high cost of production and the need for more efficient synthesis methods. Future research should focus on addressing these challenges and exploring new applications of ferric maltol in scientific research.
Conclusion:
Ferric maltol is a complex of ferric iron and maltol that has potential therapeutic and environmental applications. It has high bioavailability and low toxicity, making it an attractive candidate for various applications. The method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, future perspectives, and challenges of ferric maltol have been discussed in this paper. Further research is needed to fully understand the potential of ferric maltol in scientific research.
Conclusion:
Ferric maltol is a complex of ferric iron and maltol that has potential therapeutic and environmental applications. It has high bioavailability and low toxicity, making it an attractive candidate for various applications. The method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, future perspectives, and challenges of ferric maltol have been discussed in this paper. Further research is needed to fully understand the potential of ferric maltol in scientific research.
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