Melamine is a nitrogen-rich organic compound with the chemical formula C3H6N6. It is a white crystalline powder that is commonly used in the production of plastics, resins, and adhesives. Melamine has also been used as a food additive, particularly in China, where it has been added to milk and other dairy products to increase their protein content. However, the use of melamine in food has been linked to a number of health problems, including kidney damage and cancer. In this paper, we will explore the synthesis, biological activity, effects, applications, and future perspectives of melamine.
less than 1 mg/mL at 72° F (NTP, 1992) 0.03 M Very slightly sol in hot alc; insol in ether Sparingly sol in glycol, glycerol, pyridine; very slightly sol in ethanol; insol in benzene, carbon tetrachloride In water, 3.23X10+3 mg/L at 20 °C 3.24 mg/mL at 20 °C Solubility in water: poo
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1,3,5-Triazine-2,4,6-triamine, polymer with formaldehyde, methylated, also known as melamine-formaldehyde resin, is a thermosetting polymer that is widely used in various industrial applications. It is a white crystalline powder that is soluble in water and organic solvents. The polymer is synthesized by the reaction of melamine and formaldehyde under alkaline conditions. The resulting polymer is a cross-linked network of melamine and formaldehyde units that exhibit excellent thermal and chemical stability, mechanical strength, and resistance to moisture and abrasion.
1,3,5-Triazine-2,4,6-triamine, polymer with formaldehyde, methylated, commonly known as melamine-formaldehyde resin, is a synthetic polymer that finds extensive applications in various fields due to its unique properties. This paper aims to provide a comprehensive overview of this compound, including its synthesis methods, chemical structure, biological activity, effects on cell function, applications in different research areas, and future perspectives and challenges.
ME -143 is a derivative of triphendiol and is a highly potent, pan acting ant-cancer. It is active against every melanoma cell line tested to date and is able to sensitize melanoma cell lines to the standard of care drug, dacarbazine, and members of the platinum drug scaffold. Proof of concept studies in animal models of melanoma have demonstrated that orally delivered ME-143 retards tumour proliferation. The ME-143 mechanism of action in melanoma has not been fully elucidated. ME-143 is non-clastogenic.
PWT143, also known as ME-401, is an orally bioavailable inhibitor of the delta isoform of phosphatidylinositide 3-kinase (PI3K), with potential antineoplastic activity. Upon oral administration, PI3K-delta inhibitor PWT143 selectively inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. PI3K-delta plays a key role in the proliferation and survival of hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.