Pirlimycin is a broad-spectrum antibiotic that belongs to the lincosamide class of antibiotics. It is primarily used in veterinary medicine to treat mastitis in dairy cows. Pirlimycin is a semi-synthetic derivative of lincomycin, which was first isolated from Streptomyces lincolnensis in 1962. Pirlimycin has been shown to be effective against a wide range of gram-positive bacteria, including Staphylococcus aureus, Streptococcus agalactiae, and Streptococcus uberis.
Pirlimycin is synthesized by the chemical modification of lincomycin. The most commonly used method for the synthesis of pirlimycin is the acylation of lincomycin with 3,4-dimethoxybenzoyl chloride. This method yields pirlimycin with a purity of over 99%. However, this method is not very efficient, and the yield of pirlimycin is only around 50%. Another method for the synthesis of pirlimycin is the acylation of lincomycin with 3,4,5-trimethoxybenzoyl chloride. This method yields pirlimycin with a purity of over 99% and a yield of around 70%. Both of these methods require the use of toxic solvents and reagents, which can have negative environmental and safety considerations.
Chemical Structure and Biological Activity
Pirlimycin has a similar chemical structure to lincomycin, with the addition of a 3,4-dimethoxybenzoyl group. The mechanism of action of pirlimycin is similar to that of lincomycin, which inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Pirlimycin has been shown to be effective against a wide range of gram-positive bacteria, including Staphylococcus aureus, Streptococcus agalactiae, and Streptococcus uberis. Pirlimycin has also been shown to have a low potential for resistance development.
Pirlimycin has been shown to have a number of biological effects on cell function and signal transduction. Pirlimycin has been shown to inhibit the growth of cancer cells in vitro, and has been investigated as a potential anti-cancer agent. Pirlimycin has also been shown to have potential therapeutic effects in the treatment of inflammatory bowel disease. However, pirlimycin has also been shown to have potential toxic effects, including hepatotoxicity and nephrotoxicity.
Pirlimycin has a number of applications in medical research, including its role in drug development and clinical trials. Pirlimycin has been investigated as a potential treatment for a wide range of bacterial infections, including mastitis, pneumonia, and skin infections. Pirlimycin has also been investigated as a potential anti-cancer agent and as a treatment for inflammatory bowel disease. In environmental research, pirlimycin has been shown to have potential effects on ecosystems, and has been investigated as a potential tool for pollution management. In industrial research, pirlimycin has been used in manufacturing processes to improve product quality and efficiency.
Future Perspectives and Challenges
Despite its potential therapeutic and industrial applications, pirlimycin has a number of limitations in its use and study. Pirlimycin has been shown to have potential toxic effects, which limit its use in human medicine. Pirlimycin also has a limited spectrum of activity, which limits its use in the treatment of certain bacterial infections. Future research on pirlimycin will need to focus on developing new methods for synthesis and extraction, as well as investigating its potential therapeutic and industrial applications.
Q1: How Can I Obtain a Quote for a Product I'm Interested In?
To receive a quotation, send us an inquiry about the desired product.
The quote will cover pack size options, pricing, and availability details.
If applicable, estimated lead times for custom synthesis or sourcing will be provided.
Quotations are valid for 30 days, unless specified otherwise.
Q2: What Are the Payment Terms for Ordering Products?
New customers generally require full prepayment.
NET 30 payment terms can be arranged for customers with established credit.
Contact our customer service to set up a credit account for NET 30 terms.
We accept purchase orders (POs) from universities, research institutions, and government agencies.
Q3: Which Payment Methods Are Accepted?
Preferred methods include bank transfers (ACH/wire) and credit cards.
Request a proforma invoice for bank transfer details.
For credit card payments, ask sales representatives for a secure payment link.
Checks aren't accepted as prepayment, but they can be used for post-payment on NET 30 orders.
Q4: How Do I Place and Confirm an Order?
Orders are confirmed upon receiving official order requests.
Provide full prepayment or submit purchase orders for credit account customers.
Send purchase orders to firstname.lastname@example.org.
A confirmation email with estimated shipping date follows processing.
Q5: What's the Shipping and Delivery Process Like?
Our standard shipping partner is FedEx (Standard Overnight, 2Day, FedEx International Priority), unless otherwise agreed.
You can use your FedEx account; specify this on the purchase order or inform customer service.
Customers are responsible for customs duties and taxes on international shipments.
Q6: How Can I Get Assistance During the Ordering Process?
Reach out to our customer service representatives at email@example.com.
For ongoing order updates or questions, continue using the same email.
Remember, we're here to help! Feel free to contact us for any queries or further assistance.
Note: Kindly utilize formal channels such as professional, corporate, academic emails, etc., for inquiries. The use of personal email for inquiries is not advised.
Pirlimycin Hydrochloride is the hydrochloride salt form of pirlimycin, a derivative of clindamycin with a 6-membered ring replacing clindamycin's 5-membered ring. Compared to clindimycin, pirlimycin has increased activity against gram-positive bacteria, including Staphylococcus aureus and coagulase negative species of Staphylococcus and Streptococcus. This agent is primarily used in the treatment of mastitis in cattle.
Perastine is a naturally occurring compound that has gained significant attention in recent years due to its potential therapeutic and environmental applications. It is a member of the class of alkaloids and is found in various plant species, including Perastrella japonica and Perastrella magellanica. This paper aims to provide a comprehensive review of Perastine, including its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, future perspectives, and challenges.
Perfluoroisobutane (PFIB) is a colorless, odorless, and non-flammable gas that belongs to the family of perfluoroalkanes. It is widely used in various industrial applications, including as a refrigerant, propellant, and blowing agent. PFIB is also used in medical and environmental research due to its unique chemical and physical properties.
Peretinoin, also known as NIK-333, is a synthetic retinoid that has been extensively studied for its potential therapeutic applications in various fields, including medical, environmental, and industrial research. This paper aims to provide a comprehensive review of peretinoin, including its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, future perspectives, and challenges.
Perflubutane, also known as perfluorobutane, is a fluorocarbon compound that has gained significant attention in various fields of research due to its unique properties. It is a colorless, odorless, and non-flammable gas that is highly stable and inert. Perflubutane has been extensively studied for its potential applications in medical, environmental, and industrial research.
Tetradecafluorohexane (C6F14) is a fluorocarbon compound that belongs to the family of perfluoroalkanes. It is a colorless, odorless, and non-flammable liquid that is insoluble in water. Tetradecafluorohexane has been widely used in various fields, including medical, environmental, and industrial research.
Perfluidone is a synthetic compound that belongs to the class of perfluorinated compounds. It is a fluorinated surfactant that has been extensively studied for its potential applications in various fields, including medical, environmental, and industrial research.