Buy Piroctone olamine (BT-278681)

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Piroctone olamine

Catalog Number: BT-278681

CAS Number: 68890-66-4

Molecular Formula: C₁₆H₃₀N₂O₃

Molecular Weight: 298.42 g/mol

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Product Introduction

Description

Piroctone olamine (PO) is a broad-spectrum antifungal agent that is widely used in various industries, including pharmaceuticals, cosmetics, and personal care products. PO is a white crystalline powder that is soluble in water and has a molecular weight of 298.82 g/mol. It is a derivative of pyridine and is also known as 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone. PO has been extensively studied for its chemical structure, biological activity, and potential applications in various fields.

Properties

CAS Number

68890-66-4

Product Name

Piroctone olamine

IUPAC Name

2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one

Molecular Formula

C₁₆H₃₀N₂O₃

Molecular Weight

298.42 g/mol

InChI

InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2

InChI Key

BTSZTGGZJQFALU-UHFFFAOYSA-N

SMILES

CC1=CC(=O)N(C(=C1)CC(C)CC(C)(C)C)O.C(CO)N

Synonyms

2-Aminoethanol, compd. with 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone; 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine Salt; Octopirox; Octopyrox; Piroctone Ethanolamine Salt;

Canonical SMILES

CC1=CC(=O)N(C(=C1)CC(C)CC(C)(C)C)O.C(CO)N

Method of Synthesis or Extraction

PO can be synthesized by various methods, including the reaction of 2-amino-4-methylpyridine with 2,4,4-trimethylpentene-1 in the presence of a catalyst. Another method involves the reaction of 2-amino-4-methylpyridine with 2,4,4-trimethylpentanol in the presence of a dehydrating agent. The efficiency and yield of each method depend on the reaction conditions, such as temperature, pressure, and reaction time. Environmental and safety considerations should also be taken into account during the synthesis process to minimize the impact on the environment and ensure the safety of workers.

Chemical Structure and Biological Activity

PO has a unique chemical structure that enables it to exhibit potent antifungal activity. It works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes, leading to cell death. PO also has antibacterial and anti-inflammatory properties, making it a promising candidate for the treatment of various skin conditions, such as dandruff, seborrheic dermatitis, and acne. The bioactivity and potency of PO depend on the concentration, formulation, and mode of application.

Biological Effects

PO has been shown to have various biological effects on cell function and signal transduction. It can modulate the expression of genes involved in inflammation, apoptosis, and cell proliferation. PO has also been investigated for its potential therapeutic and toxic effects. In preclinical studies, PO has demonstrated efficacy in treating fungal infections and reducing inflammation. However, further studies are needed to determine its safety and efficacy in humans.

Applications

PO has a wide range of applications in various fields, including medical research, environmental research, and industrial research. In medical research, PO has been studied for its role in drug development, clinical trials, and findings. It has been shown to be effective in treating dandruff, seborrheic dermatitis, and acne. However, its potential side effects, such as skin irritation and allergic reactions, should be carefully monitored. In environmental research, PO has been investigated for its effects on ecosystems, role in pollution management, and sustainability and environmental impact. In industrial research, PO is used in manufacturing processes to improve product quality and efficiency. Health and safety considerations should be taken into account during the use of PO in industrial settings.

Future Perspectives and Challenges

Despite the promising potential of PO, there are still limitations in its use and study. For example, the mechanism of action of PO is not fully understood, and its safety and efficacy in humans need to be further investigated. Possible solutions and improvements include the development of new formulations and delivery systems to enhance the bioavailability and efficacy of PO. Future trends and prospects in the application of PO in scientific research include the exploration of its potential use in other fields, such as agriculture and food preservation.
Conclusion:
PO is a promising antifungal agent that has been extensively studied for its chemical structure, biological activity, and potential applications in various fields. Its unique mechanism of action and broad-spectrum activity make it a promising candidate for the treatment of various skin conditions. However, further studies are needed to determine its safety and efficacy in humans, and health and safety considerations should be taken into account during its use in various industries.

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