4'-Chloro-2,2':6',2''-terpyridine

4'-Chloro-2,2':6',2''-terpyridine (Cltpy) is a versatile ligand in coordination chemistry, known for its ability to form complexes with various transition metals. The unique structure of Cltpy allows for the introduction of substituents at the C(4') position, which can significantly alter the properties of the resulting metal complexes. These complexes have been studied for their potential applications in various fields, including supramolecular chemistry, medicinal chemistry, and material science3510.

The mechanism of action of Cltpy complexes can vary depending on the metal ion they are coordinated with. For instance, when Cltpy is complexed with platinum, it has been shown to inhibit the renal Na+,K+-ATPase by modifying specific cysteine residues, which prevents nucleotide binding and thus inhibits the pump's activity2. In the case of cadmium(II) complexes, Cltpy coordinates with the metal ion to form a complex with a specific coordination number and geometry, which can influence its biological activity17.

Biomedical Applications

Cltpy and its metal complexes have been extensively studied for their biological activities. The antibacterial properties of Cltpy complexes have been demonstrated against a range of bacteria, with some complexes showing better activity than standard antibiotics17. Additionally, Cltpy derivatives have been investigated for their potential as anticancer drugs and antimicrobials10. The modification of Cltpy with different substituents can lead to the development of new pharmacological agents with improved efficacy and specificity8.

Supramolecular Chemistry

In supramolecular chemistry, Cltpy has been utilized to form various supramolecular frameworks through hydrogen bonding interactions. These frameworks exhibit different crystallographic symmetries and packing patterns, which are influenced by subtle differences in the molecular formulae6. The ability to control the directionality and electronic communication along the coordination axis makes Cltpy a valuable ligand for constructing complex architectures3.

Material Science

Cltpy has also found applications in material science, particularly in the synthesis of functionalized terpyridines for macromolecular chemistry and nanoscience. The introduction of different functional groups onto the terpyridine at the 4'-position allows for the creation of materials with specific properties, such as ordered monolayers visualized using scanning tunneling microscopy (STM)5. Furthermore, Cltpy has been used in the large-scale synthesis of supramolecular polymers, demonstrating its utility in the construction of non-covalent architectures4.

Coordination Chemistry

The synthesis of 4'-substituted-2,2':6',2''-terpyridines has been a subject of interest due to their ability to form complexes with almost all transition metals. These complexes can be tailored for specific applications by altering the substituents at the C(4') position. The synthetic strategies for preparing these ligands have been reviewed, highlighting their importance in the field of coordination chemistry39.