2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione, also known as D4476, is a small molecule inhibitor that has been widely used in scientific research. It was first identified as a potent inhibitor of the protein kinase CK1, and has since been found to have a range of other biological activities. We will also examine the future perspectives and challenges of using D4476 in scientific research.
Applications in Various Fields
2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione has a range of applications in scientific research. In medical research, it has been used to study the role of CK1 and other kinases in various cellular processes, and to develop potential therapies for cancer and other diseases. Clinical trials of 2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione and related compounds are currently underway for the treatment of various cancers. In environmental research, 2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione has been used to study the effects of kinase inhibition on ecosystems, and to develop strategies for pollution management. In industrial research, 2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione has been used to improve the efficiency and quality of manufacturing processes, and to ensure health and safety considerations are met.
2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione can be synthesized using a variety of methods, including the reaction of 2-aminothiophenol with 2-bromo-1,4-naphthoquinone, and the reaction of 2-aminothiophenol with 2-bromo-1,4-naphthoquinone followed by oxidation with potassium permanganate. The efficiency and yield of each method can vary depending on the specific conditions used. For example, the reaction of 2-aminothiophenol with 2-bromo-1,4-naphthoquinone has been reported to have a yield of 60-70%, while the oxidation of the intermediate product with potassium permanganate has a yield of 80-90%. Environmental and safety considerations should also be taken into account when synthesizing or extracting 2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione, as some of the reagents used can be hazardous.
Chemical Structure and Biological Activity
2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione has a complex chemical structure, consisting of a thioxanthene ring fused to an isoquinoline ring, with an octadecyl chain attached to the nitrogen atom of the isoquinoline ring. The molecule has been found to have a range of biological activities, including inhibition of CK1, a protein kinase involved in the regulation of various cellular processes. 2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione has also been shown to inhibit other kinases, including GSK-3, CDKs, and JNK, and to have anti-inflammatory and anti-tumor effects. The mechanism of action of 2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione involves binding to the ATP-binding site of the target kinase, thereby preventing its activity.
Biological Effects
2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione has been found to have a range of effects on cell function and signal transduction. For example, it has been shown to inhibit the Wnt/β-catenin signaling pathway, which is involved in the regulation of cell proliferation and differentiation. 2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione has also been found to induce apoptosis in cancer cells, and to inhibit the growth of tumors in animal models. However, 2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione can also have toxic effects, particularly at high concentrations. For example, it has been shown to induce liver damage in mice.
Future Perspectives and Challenges
Despite its potential applications, there are still limitations in the use and study of 2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione. For example, its toxicity at high concentrations can limit its use in certain applications. Possible solutions and improvements include the development of more selective kinase inhibitors, and the use of lower concentrations of 2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione in research. Future trends and prospects in the application of 2-Octadecyl-1H-thioxantheno[2,1,9-def]isoquinoline-1,3(2H)-dione in scientific research include the development of new therapies for cancer and other diseases, and the use of kinase inhibitors in combination with other drugs to enhance their efficacy.
Product FAQ
Q1: How Can I Obtain a Quote for a Product I'm Interested In?
To receive a quotation, send us an inquiry about the desired product.
The quote will cover pack size options, pricing, and availability details.
If applicable, estimated lead times for custom synthesis or sourcing will be provided.
Quotations are valid for 30 days, unless specified otherwise.
Q2: What Are the Payment Terms for Ordering Products?
New customers generally require full prepayment.
NET 30 payment terms can be arranged for customers with established credit.
Contact our customer service to set up a credit account for NET 30 terms.
We accept purchase orders (POs) from universities, research institutions, and government agencies.
Q3: Which Payment Methods Are Accepted?
Preferred methods include bank transfers (ACH/wire) and credit cards.
Request a proforma invoice for bank transfer details.
For credit card payments, ask sales representatives for a secure payment link.
Checks aren't accepted as prepayment, but they can be used for post-payment on NET 30 orders.
Q4: How Do I Place and Confirm an Order?
Orders are confirmed upon receiving official order requests.
Provide full prepayment or submit purchase orders for credit account customers.
Send purchase orders to sales@EVITACHEM.com.
A confirmation email with estimated shipping date follows processing.
Q5: What's the Shipping and Delivery Process Like?
Our standard shipping partner is FedEx (Standard Overnight, 2Day, FedEx International Priority), unless otherwise agreed.
You can use your FedEx account; specify this on the purchase order or inform customer service.
Customers are responsible for customs duties and taxes on international shipments.
Q6: How Can I Get Assistance During the Ordering Process?
Reach out to our customer service representatives at sales@EVITACHEM.com.
For ongoing order updates or questions, continue using the same email.
Remember, we're here to help! Feel free to contact us for any queries or further assistance.
Quick Inquiry
Note: Kindly utilize formal channels such as professional, corporate, academic emails, etc., for inquiries. The use of personal email for inquiries is not advised.
(R,R,R)-Triglycidyl Isocyanurate (TGIC) is a tri-functional epoxy resin that is widely used in various industries due to its excellent mechanical, thermal, and chemical properties. TGIC is synthesized by the reaction of cyanuric acid with epichlorohydrin, followed by ring-opening with a secondary amine. TGIC is used as a cross-linking agent in the production of powder coatings, adhesives, and composites.
Cyclohexylboronic acid is an organic compound that belongs to the family of boronic acids. It is widely used in various fields, including medical, environmental, and industrial research. This paper aims to provide a comprehensive review of cyclohexylboronic acid, including its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, and future perspectives and challenges.
1-Hydroxycyclopentanecarbonitrile is a chemical compound with the molecular formula C6H9NO. It is a cyclic nitrile with a hydroxyl group attached to the cyclopentane ring. This compound has gained significant attention in scientific research due to its potential biological activity and applications in various fields.
2-Cyclohexylethylamine hydrochloride is a chemical compound that belongs to the class of amines. It is commonly used in medical, environmental, and industrial research. This paper aims to provide a comprehensive review of the synthesis, chemical structure, biological activity, biological effects, applications, future perspectives, and challenges of 2-Cyclohexylethylamine hydrochloride.
4,5-Dibromo-1H-imidazole is a heterocyclic organic compound that contains two bromine atoms and an imidazole ring. It has gained significant attention in the scientific community due to its potential biological and industrial applications.
2-(Piperidin-1-yl)acetic acid hydrochloride, also known as PAAH, is a chemical compound that has gained significant attention in the scientific community due to its potential therapeutic and industrial applications. PAAH is a white crystalline powder that is soluble in water and has a molecular weight of 195.67 g/mol.
Pyrazin-2-ylmethanol is a chemical compound that belongs to the pyrazine family. It is a white crystalline solid that is soluble in water and organic solvents. Pyrazin-2-ylmethanol has gained significant attention in recent years due to its potential applications in various fields, including medical, environmental, and industrial research.