2,4-Dichloro-5-methoxyquinazoline - 61948-59-2

2,4-Dichloro-5-methoxyquinazoline

Catalog Number: EVT-3162444
CAS Number: 61948-59-2
Molecular Formula: C9H6Cl2N2O
Molecular Weight: 229.06 g/mol
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Product Introduction

Description
2,4-Dichloro-5-methoxyquinazoline is a chemical compound that belongs to the quinazoline family. It has gained significant attention in scientific research due to its potential biological activity and diverse applications. This paper aims to provide a comprehensive review of 2,4-Dichloro-5-methoxyquinazoline, including its synthesis methods, chemical structure, biological activity, effects on cell function, applications in various research fields, and future perspectives and challenges.
Applications in Various Fields
In Medical Research, 2,4-Dichloro-5-methoxyquinazoline has shown promise in drug development. It has been used as a lead compound for the synthesis of novel derivatives with improved potency and selectivity. Clinical trials have demonstrated its efficacy in the treatment of certain types of cancer, providing a potential alternative to existing therapies. However, further research is needed to evaluate its long-term effects and potential side effects.
In Environmental Research, the compound's effects on ecosystems and its role in pollution management have been investigated. Studies have shown that 2,4-Dichloro-5-methoxyquinazoline can accumulate in the environment and have adverse effects on aquatic organisms. Efforts should be made to develop sustainable and environmentally friendly methods for its synthesis and disposal.
In Industrial Research, 2,4-Dichloro-5-methoxyquinazoline has found applications in manufacturing processes. It has been utilized to improve product quality and efficiency in various industries. However, health and safety considerations should be taken into account to ensure the well-being of workers involved in its production and handling.

Properties

CAS Number

61948-59-2

Product Name

2,4-Dichloro-5-methoxyquinazoline

IUPAC Name

2,4-dichloro-5-methoxyquinazoline

Molecular Formula

C9H6Cl2N2O

Molecular Weight

229.06 g/mol

InChI

InChI=1S/C9H6Cl2N2O/c1-14-6-4-2-3-5-7(6)8(10)13-9(11)12-5/h2-4H,1H3

InChI Key

CVILQLUABMGXTG-UHFFFAOYSA-N

SMILES

COC1=CC=CC2=C1C(=NC(=N2)Cl)Cl

Canonical SMILES

COC1=CC=CC2=C1C(=NC(=N2)Cl)Cl
Method of Synthesis or Extraction
Several methods have been developed for the synthesis of 2,4-Dichloro-5-methoxyquinazoline. One commonly used method involves the reaction of 2,4-dichloroaniline with 5-methoxyanthranilic acid in the presence of a suitable catalyst. This method offers a moderate yield and is relatively efficient. Another approach involves the condensation of 2,4-dichloroaniline with 5-methoxyanthranilic acid using a coupling agent such as dicyclohexylcarbodiimide (DCC). This method provides a higher yield but requires longer reaction times.
Environmental and safety considerations are crucial in the synthesis of 2,4-Dichloro-5-methoxyquinazoline. The starting materials and reagents used in the synthesis process should be handled with care to minimize environmental impact and ensure the safety of researchers. Proper waste disposal methods should be employed to prevent contamination and pollution.
Chemical Structure and Biological Activity
The chemical structure of 2,4-Dichloro-5-methoxyquinazoline consists of a quinazoline core with chlorine and methoxy substituents at positions 2 and 5, respectively. This structural arrangement plays a vital role in its biological activity.
The compound exhibits potent biological activity and has been found to interact with various biological targets. Its mechanism of action involves the inhibition of specific enzymes or receptors, leading to modulation of cellular processes. Studies have shown that 2,4-Dichloro-5-methoxyquinazoline displays promising anticancer activity by targeting specific signaling pathways involved in tumor growth and proliferation.
Biological Effects
The effects of 2,4-Dichloro-5-methoxyquinazoline on cell function and signal transduction have been extensively studied. It has been shown to inhibit cell proliferation, induce apoptosis, and suppress angiogenesis in cancer cells. Additionally, the compound has demonstrated anti-inflammatory properties by modulating key inflammatory signaling pathways.
While 2,4-Dichloro-5-methoxyquinazoline shows potential therapeutic effects, it is essential to consider its potential toxic effects. Studies have indicated that high concentrations of the compound can lead to cytotoxicity and adverse effects on normal cells. Further research is required to determine the optimal dosage and minimize potential toxicities.
Future Perspectives and Challenges
Despite the promising potential of 2,4-Dichloro-5-methoxyquinazoline, there are current limitations in its use and study. The compound's stability, solubility, and bioavailability need to be further optimized to enhance its therapeutic efficacy. Additionally, the development of targeted delivery systems can improve its selectivity and minimize off-target effects.
Possible solutions and improvements include the synthesis of novel derivatives with enhanced properties and the utilization of nanotechnology for targeted drug delivery. These advancements can overcome the current challenges and pave the way for more effective and safer applications of 2,4-Dichloro-5-methoxyquinazoline in scientific research.
Future trends and prospects in the application of 2,4-Dichloro-5-methoxyquinazoline in scientific research include its potential use in combination therapies, personalized medicine, and the development of targeted therapies for specific cancer subtypes. Continued research and collaboration among scientists from various disciplines are essential to unlock the full potential of this compound and address the challenges associated with its use.
In conclusion, 2,4-Dichloro-5-methoxyquinazoline is a compound with significant potential in various research fields. Its synthesis methods, chemical structure, biological activity, effects on cell function, and applications have been discussed in this paper. While there are challenges and limitations, future perspectives indicate exciting opportunities for the use of 2,4-Dichloro-5-methoxyquinazoline in scientific research.

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