3'-O-(t-butyldimethylsilyl)thymidine - 40733-27-5

3'-O-(t-butyldimethylsilyl)thymidine

Catalog Number: EVT-316794
CAS Number: 40733-27-5
Molecular Formula: C16H28N2O5Si
Molecular Weight: 356.49 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
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Product Introduction

Description
3'-O-(t-butyldimethylsilyl)thymidine, also known as TBS-thymidine, is a modified form of thymidine that is commonly used in scientific research. It is a nucleoside analog that has been modified to improve its stability and bioavailability. TBS-thymidine has been used in a variety of applications, including drug development, environmental research, and industrial manufacturing. In this paper, we will explore the synthesis and extraction methods of TBS-thymidine, its chemical structure and biological activity, its effects on cell function and signal transduction, its potential therapeutic and toxic effects, and its applications in various fields. We will also discuss the future perspectives and challenges of using TBS-thymidine in scientific research.
Applications in Various Fields
3'-O-(t-butyldimethylsilyl)thymidinee has a variety of applications in scientific research. In medical research, it has been used as a tool in drug development to study the effects of nucleoside analogs on cell function and signal transduction. It has also been studied as a potential treatment for cancer and viral infections.
In environmental research, 3'-O-(t-butyldimethylsilyl)thymidinee has been used to study the effects of pollutants on ecosystems. It can be used to track the movement of pollutants through food webs and to study the effects of pollutants on DNA synthesis and cell function.
In industrial research, 3'-O-(t-butyldimethylsilyl)thymidinee can be used in manufacturing processes to improve product quality and efficiency. It can also be used to study the effects of pollutants on industrial processes and to develop new methods for pollution management.

Properties

CAS Number

40733-27-5

Product Name

3'-O-(t-butyldimethylsilyl)thymidine

IUPAC Name

1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

Molecular Formula

C16H28N2O5Si

Molecular Weight

356.49 g/mol

InChI

InChI=1S/C16H28N2O5Si/c1-10-8-18(15(21)17-14(10)20)13-7-11(12(9-19)22-13)23-24(5,6)16(2,3)4/h8,11-13,19H,7,9H2,1-6H3,(H,17,20,21)/t11-,12+,13+/m0/s1

InChI Key

QAPSNMNOIOSXSQ-YNEHKIRRSA-N

SMILES

CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O[Si](C)(C)C(C)(C)C

Canonical SMILES

CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O[Si](C)(C)C(C)(C)C

Isomeric SMILES

CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O[Si](C)(C)C(C)(C)C
Method of Synthesis or Extraction
3'-O-(t-butyldimethylsilyl)thymidinee can be synthesized using a variety of methods, including chemical synthesis and enzymatic synthesis. Chemical synthesis involves the use of chemical reactions to create 3'-O-(t-butyldimethylsilyl)thymidinee from its precursor molecules. Enzymatic synthesis involves the use of enzymes to catalyze the formation of 3'-O-(t-butyldimethylsilyl)thymidinee from its precursor molecules.
The efficiency and yield of each method can vary depending on the specific conditions used. Chemical synthesis methods can have high yields but may also produce toxic byproducts and require harsh reaction conditions. Enzymatic synthesis methods can have lower yields but are generally more environmentally friendly and require milder reaction conditions.
Environmental and safety considerations are important when synthesizing 3'-O-(t-butyldimethylsilyl)thymidinee. Chemical synthesis methods can produce toxic byproducts and require the use of hazardous chemicals. Enzymatic synthesis methods are generally more environmentally friendly but may require the use of genetically modified organisms or other specialized equipment.
Chemical Structure and Biological Activity
3'-O-(t-butyldimethylsilyl)thymidinee has a modified chemical structure that includes a t-butyldimethylsilyl group attached to the 3'-position of the thymidine molecule. This modification improves the stability and bioavailability of 3'-O-(t-butyldimethylsilyl)thymidinee, making it more effective in scientific research.
The mechanism of action and biological targets of 3'-O-(t-butyldimethylsilyl)thymidinee are not fully understood. However, it is known to be a nucleoside analog that can be incorporated into DNA during replication. This incorporation can disrupt DNA synthesis and lead to cell death.
3'-O-(t-butyldimethylsilyl)thymidinee has been shown to have bioactivity and potency in a variety of applications. It has been used as a tool in drug development to study the effects of nucleoside analogs on cell function and signal transduction. It has also been used in environmental research to study the effects of pollutants on ecosystems.
Biological Effects
3'-O-(t-butyldimethylsilyl)thymidinee can have a variety of effects on cell function and signal transduction. It has been shown to disrupt DNA synthesis and lead to cell death. It can also affect the expression of genes involved in cell growth and differentiation.
3'-O-(t-butyldimethylsilyl)thymidinee has potential therapeutic and toxic effects. It has been studied as a potential treatment for cancer and viral infections. However, it can also have toxic effects on healthy cells and tissues.
Future Perspectives and Challenges
The use of 3'-O-(t-butyldimethylsilyl)thymidinee in scientific research is still limited by several challenges. One challenge is the limited understanding of its mechanism of action and biological targets. Another challenge is the potential toxic effects on healthy cells and tissues.
Possible solutions and improvements include the development of new synthesis methods that are more environmentally friendly and the use of advanced imaging techniques to study the effects of 3'-O-(t-butyldimethylsilyl)thymidinee on cell function and signal transduction.
Future trends and prospects in the application of 3'-O-(t-butyldimethylsilyl)thymidinee in scientific research include the development of new drugs and therapies based on its nucleoside analog properties. It may also be used to study the effects of pollutants on ecosystems and to develop new methods for pollution management and sustainability.

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