Maleimide-PEG12-NHS ester - 756525-92-5

Maleimide-PEG12-NHS ester

Catalog Number: EVT-3566285
CAS Number: 756525-92-5
Molecular Formula: C38H63N3O19
Molecular Weight: 865.9 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
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Product Introduction

Description
Maleimide-PEG12-NHS ester is a chemical compound widely used in various scientific research fields, including medical, environmental, and industrial research. This paper aims to provide an overview of the synthesis methods, chemical structure, biological activity, and potential applications of Maleimide-PEG12-NHS ester. Additionally, it discusses the current limitations, future perspectives, and challenges associated with its use and study.
Applications in Various Fields
In Medical Research, Maleimide-PEG12-NHS ester plays a crucial role in drug development. It enables the targeted delivery of therapeutic agents, improving their selectivity and reducing systemic toxicity. Clinical trials have demonstrated promising results, highlighting the benefits of Maleimide-PEG12-NHS ester in improving treatment outcomes. However, potential side effects, such as immunogenicity and allergic reactions, need to be carefully monitored.
In Environmental Research, Maleimide-PEG12-NHS ester is used to study its effects on ecosystems and pollution management. Its ability to conjugate with environmental pollutants allows for the development of efficient remediation strategies. However, the sustainability and environmental impact of its usage should be considered to minimize any adverse effects on the environment.
In Industrial Research, Maleimide-PEG12-NHS ester finds applications in manufacturing processes, improving product quality, and efficiency. Its use in various industries, such as pharmaceuticals and materials science, enhances the development of innovative products. Health and safety considerations are crucial during industrial-scale production to ensure worker safety and minimize environmental risks.

Properties

CAS Number

756525-92-5

Product Name

Maleimide-PEG12-NHS ester

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Molecular Formula

C38H63N3O19

Molecular Weight

865.9 g/mol

InChI

InChI=1S/C38H63N3O19/c42-33(5-8-40-34(43)1-2-35(40)44)39-7-10-49-12-14-51-16-18-53-20-22-55-24-26-57-28-30-59-32-31-58-29-27-56-25-23-54-21-19-52-17-15-50-13-11-48-9-6-38(47)60-41-36(45)3-4-37(41)46/h1-2H,3-32H2,(H,39,42)

InChI Key

LWNZLSLPQXOOAO-UHFFFAOYSA-N

SMILES

C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O

Canonical SMILES

C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O
Method of Synthesis or Extraction
Maleimide-PEG12-NHS ester can be synthesized using several commonly used methods, including the reaction of maleimide with PEG12 and NHS ester. The efficiency and yield of each method may vary depending on the specific reaction conditions, such as temperature, solvent, and catalysts. Environmental and safety considerations are crucial during the synthesis process to minimize any potential hazards and ensure sustainable production.
Chemical Structure and Biological Activity
Maleimide-PEG12-NHS ester possesses a unique chemical structure, consisting of a maleimide group, a polyethylene glycol (PEG) chain with 12 ethylene glycol units, and an N-hydroxysuccinimide (NHS) ester moiety. This structure enables Maleimide-PEG12-NHS ester to exhibit specific biological activities and interact with various biological targets.
The mechanism of action involves the NHS ester group reacting with primary amines, forming stable amide bonds. This property allows for the conjugation of Maleimide-PEG12-NHS ester to biomolecules, such as proteins and peptides, facilitating targeted drug delivery and bioconjugation strategies.
Biological Effects
Maleimide-PEG12-NHS ester has been shown to have significant effects on cell function and signal transduction. By conjugating with specific biomolecules, it can modulate cellular processes, including receptor-ligand interactions, protein-protein interactions, and intracellular signaling pathways. These effects can lead to potential therapeutic benefits, such as enhanced drug efficacy, improved pharmacokinetics, and reduced off-target effects.
However, it is essential to consider potential toxic effects associated with Maleimide-PEG12-NHS ester usage. Careful evaluation of its cytotoxicity, immunogenicity, and long-term effects is necessary to ensure its safe application in various research areas.
Future Perspectives and Challenges
Despite the significant advancements in the use of Maleimide-PEG12-NHS ester, several limitations and challenges remain. The synthesis methods need further optimization to improve efficiency and yield. Additionally, the potential toxicity and immunogenicity of Maleimide-PEG12-NHS ester require comprehensive evaluation to ensure its safe application.
Possible solutions and improvements include the development of novel synthesis approaches, such as green chemistry methods, to enhance sustainability and reduce environmental impact. Furthermore, advancements in understanding the biological effects and mechanisms of action will contribute to the development of more targeted and effective applications.
Future trends and prospects in the application of Maleimide-PEG12-NHS ester in scientific research include its integration with emerging technologies, such as nanomedicine and gene therapy. These advancements hold great potential for personalized medicine and precision therapeutics.
In conclusion, Maleimide-PEG12-NHS ester is a versatile compound with diverse applications in medical, environmental, and industrial research. Its unique chemical structure, biological activity, and conjugation capabilities make it a valuable tool in various scientific fields. However, further research and development are necessary to overcome current limitations and maximize its potential benefits while ensuring safety and sustainability.

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