2-Chloro-5-iodothiophene - 28712-49-4

2-Chloro-5-iodothiophene

Catalog Number: EVT-389454
CAS Number: 28712-49-4
Molecular Formula: C4H2ClIS
Molecular Weight: 244.48 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
Price:

Product Introduction

Description
2-Chloro-5-iodothiophene is a heterocyclic compound that has gained significant attention in recent years due to its potential applications in various fields, including medical, environmental, and industrial research. This paper aims to provide an overview of the synthesis, chemical structure, biological activity, and applications of 2-Chloro-5-iodothiophene.
Applications in Various Fields
In medical research, 2-Chloro-5-iodothiophene has been investigated for its potential role in drug development. Several studies have reported the development of novel kinase inhibitors based on the structure of 2-Chloro-5-iodothiophene, which have shown promising results in preclinical studies. Clinical trials are currently underway to evaluate the safety and efficacy of these compounds in treating various types of cancer. However, the use of 2-Chloro-5-iodothiophene in medical research also raises ethical concerns about the use of animals in testing and the potential risks to human subjects.
In environmental research, 2-Chloro-5-iodothiophene has been investigated for its effects on ecosystems and its potential role in pollution management. Studies have shown that this compound can have toxic effects on aquatic organisms, highlighting the need for further research to determine its environmental impact. In industrial research, 2-Chloro-5-iodothiophene has been used in manufacturing processes to improve product quality and efficiency. However, health and safety considerations should be taken into account when handling this compound, as it can be toxic and hazardous.

Properties

CAS Number

28712-49-4

Product Name

2-Chloro-5-iodothiophene

IUPAC Name

2-chloro-5-iodothiophene

Molecular Formula

C4H2ClIS

Molecular Weight

244.48 g/mol

InChI

InChI=1S/C4H2ClIS/c5-3-1-2-4(6)7-3/h1-2H

InChI Key

IJEUNSXYUQTZPT-UHFFFAOYSA-N

SMILES

C1=C(SC(=C1)I)Cl

Canonical SMILES

C1=C(SC(=C1)I)Cl
Method of Synthesis or Extraction
2-Chloro-5-iodothiophene can be synthesized using various methods, including the Pd-catalyzed cross-coupling reaction, the iodination of 2-chlorothiophene, and the reaction of 2-chlorothiophene with iodine and a copper catalyst. The efficiency and yield of each method vary depending on the reaction conditions and the starting materials used. For example, the Pd-catalyzed cross-coupling reaction has been reported to yield up to 90% of the desired product, while the iodination of 2-chlorothiophene has a lower yield of around 50%. Environmental and safety considerations should also be taken into account when selecting a method for synthesizing 2-Chloro-5-iodothiophene, as some methods may involve the use of toxic or hazardous reagents.
Chemical Structure and Biological Activity
The chemical structure of 2-Chloro-5-iodothiophene consists of a thiophene ring with a chlorine atom at position 2 and an iodine atom at position 5. This compound has been found to exhibit potent biological activity, particularly as an inhibitor of protein kinases. It has been shown to inhibit the activity of several kinases, including JAK2, FLT3, and BTK, which are involved in various cellular processes such as cell growth, differentiation, and survival. The mechanism of action of 2-Chloro-5-iodothiophene involves the binding of the compound to the ATP-binding site of the kinase, thereby preventing the phosphorylation of downstream targets.
Biological Effects
The inhibition of protein kinases by 2-Chloro-5-iodothiophene has been shown to have various effects on cell function and signal transduction. For example, the inhibition of JAK2 by this compound has been found to reduce the proliferation of cancer cells and induce apoptosis. In addition, the inhibition of FLT3 has been shown to reduce the growth of leukemia cells. However, the use of 2-Chloro-5-iodothiophene in medical research also raises concerns about potential toxic effects. Studies have shown that this compound can cause liver toxicity and hematological toxicity in animal models, highlighting the need for further research to determine its safety and potential therapeutic effects.
Future Perspectives and Challenges
Despite the potential applications of 2-Chloro-5-iodothiophene in various fields, there are still limitations in its use and study. For example, the toxicity of this compound and its potential side effects need to be further investigated to ensure its safety in medical and environmental applications. In addition, the development of more efficient and sustainable methods for synthesizing 2-Chloro-5-iodothiophene is needed to reduce the environmental impact of its production. Future trends and prospects in the application of 2-Chloro-5-iodothiophene in scientific research will depend on the outcomes of ongoing studies and the development of new technologies and methods.

Product FAQ

Q1: How Can I Obtain a Quote for a Product I'm Interested In?
  • To receive a quotation, send us an inquiry about the desired product.
  • The quote will cover pack size options, pricing, and availability details.
  • If applicable, estimated lead times for custom synthesis or sourcing will be provided.
  • Quotations are valid for 30 days, unless specified otherwise.
Q2: What Are the Payment Terms for Ordering Products?
  • New customers generally require full prepayment.
  • NET 30 payment terms can be arranged for customers with established credit.
  • Contact our customer service to set up a credit account for NET 30 terms.
  • We accept purchase orders (POs) from universities, research institutions, and government agencies.
Q3: Which Payment Methods Are Accepted?
  • Preferred methods include bank transfers (ACH/wire) and credit cards.
  • Request a proforma invoice for bank transfer details.
  • For credit card payments, ask sales representatives for a secure payment link.
  • Checks aren't accepted as prepayment, but they can be used for post-payment on NET 30 orders.
Q4: How Do I Place and Confirm an Order?
  • Orders are confirmed upon receiving official order requests.
  • Provide full prepayment or submit purchase orders for credit account customers.
  • Send purchase orders to sales@EVITACHEM.com.
  • A confirmation email with estimated shipping date follows processing.
Q5: What's the Shipping and Delivery Process Like?
  • Our standard shipping partner is FedEx (Standard Overnight, 2Day, FedEx International Priority), unless otherwise agreed.
  • You can use your FedEx account; specify this on the purchase order or inform customer service.
  • Customers are responsible for customs duties and taxes on international shipments.
Q6: How Can I Get Assistance During the Ordering Process?
  • Reach out to our customer service representatives at sales@EVITACHEM.com.
  • For ongoing order updates or questions, continue using the same email.
  • Remember, we're here to help! Feel free to contact us for any queries or further assistance.

Quick Inquiry

 Note: Kindly utilize formal channels such as professional, corporate, academic emails, etc., for inquiries. The use of personal email for inquiries is not advised.