Nialamide - 51-12-7

Nialamide

Catalog Number: EVT-252983
CAS Number: 51-12-7
Molecular Formula: C16H18N4O2
Molecular Weight: 298.34 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.

Product Introduction

Description
Nialamide is a monoamine oxidase inhibitor (MAOI) that was first synthesized in the 1950s. It is a potent antidepressant and has been used in the treatment of depression, anxiety, and other psychiatric disorders. Nialamide is also known for its potential therapeutic effects in the treatment of cancer and other diseases.
Applications in Various Fields
In medical research, nialamide has been used in drug development and clinical trials for the treatment of depression and other psychiatric disorders. It has also been studied for its potential therapeutic effects in the treatment of cancer and other diseases. In environmental research, nialamide has been studied for its effects on ecosystems and its role in pollution management. In industrial research, nialamide has been used in manufacturing processes to improve product quality and efficiency. Health and safety considerations must be taken into account when using nialamide in industrial settings.

Properties

CAS Number

51-12-7

Product Name

Nialamide

IUPAC Name

N-benzyl-3-[2-(pyridine-4-carbonyl)hydrazinyl]propanamide

Molecular Formula

C16H18N4O2

Molecular Weight

298.34 g/mol

InChI

InChI=1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22)

InChI Key

NOIIUHRQUVNIDD-UHFFFAOYSA-N

SMILES

C1=CC=C(C=C1)CNC(=O)CCNNC(=O)C2=CC=NC=C2

Solubility

Freely soluble in acidic solvents
In water, 2,270 mg/L at 25 °C (est)
33.6 [ug/mL]

Synonyms

Nialamide

Canonical SMILES

C1=CC=C(C=C1)CNC(=O)CCNNC(=O)C2=CC=NC=C2
Method of Synthesis or Extraction
Nialamide can be synthesized by several methods, including the reaction of 2-chloro-4-nitroaniline with ethyl formate, followed by reduction with sodium borohydride. Another method involves the reaction of 2-chloro-4-nitroaniline with ethyl chloroformate, followed by reduction with lithium aluminum hydride. The yield and efficiency of each method vary, with the first method yielding a higher percentage of nialamide. Environmental and safety considerations must also be taken into account during the synthesis process, as some of the reagents used can be hazardous.
Chemical Structure and Biological Activity
Nialamide has a chemical formula of C12H13N3O2 and a molecular weight of 231.25 g/mol. Its chemical structure consists of a benzene ring, a nitro group, and an amine group. Nialamide is a reversible inhibitor of monoamine oxidase (MAO), an enzyme that breaks down neurotransmitters such as serotonin, dopamine, and norepinephrine. By inhibiting MAO, nialamide increases the levels of these neurotransmitters in the brain, leading to its antidepressant effects. Nialamide has also been shown to have potential therapeutic effects in the treatment of cancer and other diseases.
Biological Effects
Nialamide has been shown to affect cell function and signal transduction by increasing the levels of neurotransmitters in the brain. It has also been shown to have potential therapeutic and toxic effects. In addition to its antidepressant effects, nialamide has been shown to have antitumor effects in animal models. However, it can also cause side effects such as dizziness, dry mouth, and gastrointestinal disturbances.
Future Perspectives and Challenges
Current limitations in the use and study of nialamide include its potential side effects and the need for further research to fully understand its mechanisms of action. Possible solutions and improvements include the development of new and more effective MAO inhibitors and the use of nialamide in combination with other drugs for the treatment of cancer and other diseases. Future trends and prospects in the application of nialamide in scientific research include the development of new therapeutic uses and the exploration of its potential in personalized medicine.
Conclusion:
Nialamide is a potent antidepressant and has potential therapeutic effects in the treatment of cancer and other diseases. Its chemical structure and biological activity have been well-studied, and it has been used in drug development and clinical trials for the treatment of depression and other psychiatric disorders. However, its potential side effects and the need for further research to fully understand its mechanisms of action must be taken into account. Nialamide has applications in medical, environmental, and industrial research, and its future prospects in scientific research are promising.

Product FAQ

Q1: How Can I Obtain a Quote for a Product I'm Interested In?
  • To receive a quotation, send us an inquiry about the desired product.
  • The quote will cover pack size options, pricing, and availability details.
  • If applicable, estimated lead times for custom synthesis or sourcing will be provided.
  • Quotations are valid for 30 days, unless specified otherwise.
Q2: What Are the Payment Terms for Ordering Products?
  • New customers generally require full prepayment.
  • NET 30 payment terms can be arranged for customers with established credit.
  • Contact our customer service to set up a credit account for NET 30 terms.
  • We accept purchase orders (POs) from universities, research institutions, and government agencies.
Q3: Which Payment Methods Are Accepted?
  • Preferred methods include bank transfers (ACH/wire) and credit cards.
  • Request a proforma invoice for bank transfer details.
  • For credit card payments, ask sales representatives for a secure payment link.
  • Checks aren't accepted as prepayment, but they can be used for post-payment on NET 30 orders.
Q4: How Do I Place and Confirm an Order?
  • Orders are confirmed upon receiving official order requests.
  • Provide full prepayment or submit purchase orders for credit account customers.
  • Send purchase orders to sales@EVITACHEM.com.
  • A confirmation email with estimated shipping date follows processing.
Q5: What's the Shipping and Delivery Process Like?
  • Our standard shipping partner is FedEx (Standard Overnight, 2Day, FedEx International Priority), unless otherwise agreed.
  • You can use your FedEx account; specify this on the purchase order or inform customer service.
  • Customers are responsible for customs duties and taxes on international shipments.
Q6: How Can I Get Assistance During the Ordering Process?
  • Reach out to our customer service representatives at sales@EVITACHEM.com.
  • For ongoing order updates or questions, continue using the same email.
  • Remember, we're here to help! Feel free to contact us for any queries or further assistance.

Quick Inquiry

 Note: Kindly utilize formal channels such as professional, corporate, academic emails, etc., for inquiries. The use of personal email for inquiries is not advised.