Cyclamic acid - 100-88-9

Cyclamic acid

Catalog Number: EVT-253016
CAS Number: 100-88-9
Molecular Formula: C6H13NO3S
Molecular Weight: 179.24 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
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Product Introduction

Description
Cyclamic acid is a synthetic sweetener that is widely used in the food and beverage industry as a sugar substitute. It was first discovered in 1937 by Michael Sveda, a graduate student at the University of Illinois. Cyclamic acid is approximately 30 times sweeter than sugar and has no calories, making it an attractive alternative to sugar for people who are trying to lose weight or manage their blood sugar levels.
Applications in Various Fields
Cyclamic acid has a wide range of applications in various fields. In medical research, cyclamic acid has been studied for its role in drug development and clinical trials. It has been used as a sugar substitute in medications and dietary supplements. Cyclamic acid has also been studied for its potential therapeutic effects in the treatment of diabetes and obesity. In environmental research, cyclamic acid has been studied for its effects on ecosystems and its role in pollution management. Cyclamic acid has been used in wastewater treatment to remove heavy metals and other pollutants. In industrial research, cyclamic acid has been used in manufacturing processes to improve product quality and efficiency. Cyclamic acid has also been used in the production of cosmetics and personal care products.

Properties

CAS Number

100-88-9

Product Name

Cyclamic acid

IUPAC Name

cyclohexylsulfamic acid

Molecular Formula

C6H13NO3S

Molecular Weight

179.24 g/mol

InChI

InChI=1S/C6H13NO3S/c8-11(9,10)7-6-4-2-1-3-5-6/h6-7H,1-5H2,(H,8,9,10)

InChI Key

HCAJEUSONLESMK-UHFFFAOYSA-N

SMILES

C1CCC(CC1)NS(=O)(=O)O

Solubility

1 G DISSOLVES IN ABOUT 7.5 ML OF WATER, 4 ML OF ALC, 4 ML OF PROPYLENE GLYCOL, OR 6 ML OF ACETONE; SLIGHTLY SOL IN CHLOROFORM AND INSOL IN HEXANE
Very soluble in alkali
Soluble in alcohol; insoluble in oils
In water, 1.0X10+6 mg/L /SRC:miscible/ at 25 °C (est)

Synonyms

Calcium Cyclamate
Cyclamate
Cyclamate Calcium (2:1) Salt
Cyclamate, Calcium
Cyclamate, Calcium (2:1) Salt, Dihydrate
Cyclamate, Potassium
Cyclamate, Sodium
Cyclamate, Sodium Salt
Cyclamates
Cyclamic Acid
Potassium Cyclamate
Sodium Cyclamate

Canonical SMILES

C1CCC(CC1)NS(=O)(=O)O
Method of Synthesis or Extraction
Cyclamic acid is synthesized by the sulfonation of cyclohexylamine with sulfur trioxide. The reaction yields cyclamic acid and cyclohexylsulfamic acid. The two compounds are separated by crystallization, and cyclamic acid is obtained in a pure form. The efficiency and yield of this method are high, and the process is relatively simple. However, the use of sulfur trioxide poses environmental and safety considerations, as it is a highly reactive and corrosive substance.
Chemical Structure and Biological Activity
Cyclamic acid is a cyclic sulfamic acid with the chemical formula C6H13NO3S. It is a white crystalline powder that is soluble in water and ethanol. Cyclamic acid is a non-nutritive sweetener that is not metabolized by the body, and it does not contribute to caloric intake. The mechanism of action of cyclamic acid involves binding to sweet taste receptors on the tongue, which triggers a signal to the brain that the food or beverage is sweet. Cyclamic acid has been shown to have a high potency and a long-lasting sweetness.
Biological Effects
Cyclamic acid has been shown to have no significant effects on cell function and signal transduction. However, there are potential therapeutic and toxic effects associated with its use. Cyclamic acid has been studied for its potential role in the treatment of diabetes, as it does not raise blood sugar levels. However, there are concerns about the safety of cyclamic acid, as it has been shown to cause bladder cancer in rats when consumed in high doses. The International Agency for Research on Cancer has classified cyclamic acid as a possible human carcinogen.
Future Perspectives and Challenges
Despite its potential benefits, cyclamic acid faces several challenges in its use and study. One of the main challenges is the safety concerns associated with its use. The carcinogenic potential of cyclamic acid needs to be further studied to determine its safety for human consumption. Another challenge is the limited availability of cyclamic acid, as it is not widely produced or used compared to other sweeteners. Future research should focus on developing more efficient and sustainable methods of synthesis or extraction of cyclamic acid. Additionally, more research is needed to explore the potential therapeutic effects of cyclamic acid in the treatment of various diseases.
Conclusion:
Cyclamic acid is a synthetic sweetener that has a wide range of applications in various fields. Its high potency and long-lasting sweetness make it an attractive alternative to sugar for people who are trying to manage their weight or blood sugar levels. However, the safety concerns associated with its use need to be further studied to determine its safety for human consumption. Future research should focus on developing more efficient and sustainable methods of synthesis or extraction of cyclamic acid and exploring its potential therapeutic effects in the treatment of various diseases.

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