4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile, also known as DPCPX, is a potent and selective antagonist of the adenosine A1 receptor. It has been extensively studied for its potential therapeutic applications in various diseases, including cardiovascular, neurological, and inflammatory disorders.
Applications in Various Fields
4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile has been widely used in medical research for its potential therapeutic applications. It has been tested in various preclinical and clinical trials for the treatment of cardiovascular, neurological, and inflammatory disorders. In environmental research, 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile has been used to study its effects on ecosystems and its role in pollution management. In industrial research, 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile has been used in manufacturing processes to improve product quality and efficiency. However, the use of 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile requires careful consideration of health and safety considerations, including its potential toxic effects.
4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile can be synthesized using various methods, including the Buchwald-Hartwig coupling reaction, Suzuki-Miyaura coupling reaction, and Sonogashira coupling reaction. The Buchwald-Hartwig coupling reaction is the most commonly used method for the synthesis of 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile. It involves the reaction of 4-bromo-1,1'-biphenyl with (3R)-3-(dimethylamino)pyrrolidine and 4-cyanophenylboronic acid in the presence of a palladium catalyst. The efficiency and yield of this method are high, with a yield of up to 90%. However, this method requires the use of toxic and hazardous chemicals, such as palladium catalysts and organic solvents, which pose environmental and safety considerations.
Chemical Structure and Biological Activity
4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile is a selective antagonist of the adenosine A1 receptor, which is a G protein-coupled receptor that plays a crucial role in various physiological processes, including cardiovascular function, neurotransmission, and inflammation. 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile binds to the A1 receptor with high affinity and specificity, inhibiting its activation by adenosine. This mechanism of action results in the inhibition of various downstream signaling pathways, including the cAMP-PKA pathway, which regulates cell function and signal transduction. 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile has been shown to exhibit potent bioactivity and potency, with an IC50 value of 0.6 nM for the A1 receptor.
Biological Effects
4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile has been extensively studied for its potential therapeutic and toxic effects in various diseases. In cardiovascular diseases, 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile has been shown to exhibit cardioprotective effects by reducing myocardial ischemia-reperfusion injury and improving cardiac function. In neurological disorders, 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile has been shown to exhibit neuroprotective effects by reducing neuronal damage and inflammation. In inflammatory disorders, 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile has been shown to exhibit anti-inflammatory effects by reducing the production of pro-inflammatory cytokines. However, 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile also exhibits potential toxic effects, including hepatotoxicity and nephrotoxicity, which require further investigation.
Future Perspectives and Challenges
Despite its potential therapeutic applications, the use of 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile is limited by its potential toxic effects and the lack of understanding of its long-term effects. Future research should focus on developing safer and more effective analogs of 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile and investigating its long-term effects on human health and the environment. Additionally, the use of 4'-(3-((3R)-3-(Dimethylamino)pyrrolidinyl)propoxy)(1,1'-biphenyl)-4-carbonitrile in clinical trials requires careful consideration of its potential toxic effects and the development of appropriate safety measures.
Product FAQ
Q1: How Can I Obtain a Quote for a Product I'm Interested In?
To receive a quotation, send us an inquiry about the desired product.
The quote will cover pack size options, pricing, and availability details.
If applicable, estimated lead times for custom synthesis or sourcing will be provided.
Quotations are valid for 30 days, unless specified otherwise.
Q2: What Are the Payment Terms for Ordering Products?
New customers generally require full prepayment.
NET 30 payment terms can be arranged for customers with established credit.
Contact our customer service to set up a credit account for NET 30 terms.
We accept purchase orders (POs) from universities, research institutions, and government agencies.
Q3: Which Payment Methods Are Accepted?
Preferred methods include bank transfers (ACH/wire) and credit cards.
Request a proforma invoice for bank transfer details.
For credit card payments, ask sales representatives for a secure payment link.
Checks aren't accepted as prepayment, but they can be used for post-payment on NET 30 orders.
Q4: How Do I Place and Confirm an Order?
Orders are confirmed upon receiving official order requests.
Provide full prepayment or submit purchase orders for credit account customers.
Send purchase orders to sales@EVITACHEM.com.
A confirmation email with estimated shipping date follows processing.
Q5: What's the Shipping and Delivery Process Like?
Our standard shipping partner is FedEx (Standard Overnight, 2Day, FedEx International Priority), unless otherwise agreed.
You can use your FedEx account; specify this on the purchase order or inform customer service.
Customers are responsible for customs duties and taxes on international shipments.
Q6: How Can I Get Assistance During the Ordering Process?
Reach out to our customer service representatives at sales@EVITACHEM.com.
For ongoing order updates or questions, continue using the same email.
Remember, we're here to help! Feel free to contact us for any queries or further assistance.
Quick Inquiry
Note: Kindly utilize formal channels such as professional, corporate, academic emails, etc., for inquiries. The use of personal email for inquiries is not advised.
A 331440 dihydrochloride is a chemical compound that has gained significant attention in the scientific community due to its potential therapeutic and industrial applications. It is a small molecule inhibitor that targets protein kinases, which are enzymes involved in cell signaling and regulation.
2'-Amino-2'-deoxyuridine (AU) is a nucleoside analog that has been extensively studied for its potential therapeutic and diagnostic applications. It is a modified form of uridine, a nucleoside that is a building block of RNA. AU has been shown to have antiviral, antitumor, and immunomodulatory properties, making it a promising candidate for drug development. We will also explore the future perspectives and challenges in the use and study of AU.
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine is a heterocyclic compound that has gained significant attention in the scientific community due to its potential therapeutic and industrial applications. This compound is a pyrrolopyrimidine derivative that exhibits a unique chemical structure and biological activity.
Methyl (1S,3S,6R,8S)-3-phenyl-2,4,7-trioxabicyclo[4.2.0]octane-8-carboxylate is a chemical compound that belongs to the family of bicyclic compounds. It is commonly used in medical, environmental, and industrial research due to its unique chemical structure and biological activity.
2',3'-Didehydro-2',3'-dideoxyuridine (d4T) is a synthetic nucleoside analogue that has been used as an antiretroviral drug for the treatment of human immunodeficiency virus (HIV) infection. It was first synthesized in the 1980s and has since been used in combination with other antiretroviral drugs to improve the efficacy of HIV treatment. In addition to its medical applications, d4T has also been studied for its potential use in environmental and industrial research.
Epiquinidine is a natural alkaloid that is derived from the bark of the Cinchona tree. It is a stereoisomer of quinidine and has been used as an antiarrhythmic agent for many years. Epiquinidine has also been found to have potential therapeutic effects in other areas of medicine, such as cancer treatment and pain management. In this paper, we will explore the methods of synthesis or extraction of epiquinidine, its chemical structure and biological activity, its effects on cell function and signal transduction, its potential therapeutic and toxic effects, and its applications in medical, environmental, and industrial research. We will also discuss the future perspectives and challenges of using epiquinidine in scientific research.
Cyclouridine is a cyclic nucleoside that has gained significant attention in recent years due to its potential therapeutic and environmental applications. It is a modified form of uridine, where the ribose ring is cyclized to form a five-membered ring. Cyclouridine has been found to exhibit various biological activities, including antiviral, anticancer, and anti-inflammatory properties.
2,2'-Anhydro-5-methyluridine is a nucleoside analog that has gained significant attention in recent years due to its potential therapeutic and industrial applications. It is a modified form of uridine, a nucleoside that is found in RNA and plays a crucial role in various biological processes.