Ly2584702 is a small molecule inhibitor that has gained significant attention in the scientific community due to its potential therapeutic applications. It is a selective inhibitor of the protein kinase C (PKC) family, which plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis.
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LY-2584702 hydrochloride is a small molecule inhibitor that has shown promising results in preclinical studies for the treatment of various types of cancer. It is a potent and selective inhibitor of the protein kinase CK2, which plays a crucial role in cell proliferation, survival, and differentiation.
(S)-Mcpg, also known as (S)-methyl-4-carboxyphenylglycine, is a synthetic compound that has gained significant attention in the field of medical research due to its potential therapeutic effects. It is a derivative of the neurotransmitter glutamate and acts as an agonist of the metabotropic glutamate receptor subtype 4 (mGluR4).
Flavopiridol hydrochloride is a synthetic flavonoid that has been extensively studied for its potential therapeutic applications in various diseases, including cancer, viral infections, and inflammatory disorders. It is a potent inhibitor of cyclin-dependent kinases (CDKs), which play a crucial role in cell cycle regulation and proliferation.
Haloperidol hydrochloride is a potent antipsychotic drug that is widely used in the treatment of various psychiatric disorders. It belongs to the class of butyrophenones and acts by blocking the dopamine receptors in the brain. Haloperidol hydrochloride is a crystalline powder that is soluble in water and alcohol. It is available in various forms, including tablets, injections, and oral solutions.
Cortexolone is a synthetic steroid that has gained significant attention in recent years due to its potential therapeutic applications. It is a derivative of the natural hormone cortisol and has been shown to possess anti-inflammatory, anti-proliferative, and anti-androgenic properties.
WHI-P180 hydrochloride is a small molecule inhibitor that has been extensively studied for its potential therapeutic applications. It is a potent inhibitor of Janus kinase 3 (JAK3), a tyrosine kinase that plays a crucial role in the immune system. WHI-P180 hydrochloride has been shown to have anti-inflammatory and immunosuppressive effects, making it a promising candidate for the treatment of autoimmune diseases and transplant rejection.
Fluconazole (mesylate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.Target: AntifungalFluconazole (mesylate) is the mesylate salt form of fluconazole, which is a triazole antifungal intended for oral treatment of superficial and systemic mycoses. In tests done in standard mycological media, the compound had minimal inhibitory concentrations against pathogenic Candida species that were usually in excess of 100 mg/l. Fluconazole inhibited branching and hyphal development in C. albicans at concentrations as low as 10(-6) M (0.3 mg/l), but miconazole and ketoconazole were still active in these tests at concentrations 100 times lower than this [1]. Oral fluconazole was not associated with a significantly increased risk of birth defects overall or of 14 of the 15 specific birth defects of previous concern. Fluconazole exposure may confer an increased risk of tetralogy of Fallot [2]. Fluconazole is predicted to be ineffective against Cryptococcus gattii in the koala as a sole therapeutic agent administered at 10 mg/kg p.o. every 12 h [3].Clinical indications: Balanitis; Candida infection; Cryptococcus infection; Cryptococcus neoformans meningitis; Dermatomycosis; Female genital tract infection; Fungal infection; Fungal respiratory tract infection; Fungal urinary tract infection; Prophylaxis; Tinea capitis; Tinea corporis; Tinea cruris; Tinea pedis .Toxicity: Symptoms of overdose include hallucinations and paranoid behavior.
Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO2014059368A1 Compound 1-5, has an IC50 of 0.755-1.02 nM for BTK.IC50 & Target: 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.57 nM (BMX), 5.99-6.92 nM (LCK), 33.8-36.3 nM (Src), 0.187-0.198 μM (ITK),5.34-4.87 μM (JAK3)[1]InVitro: Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC, BTK (Bruton/'s Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine- mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells[1].