Amibegron hydrochloride - 121524-09-2

Amibegron hydrochloride

Catalog Number: EVT-254457
CAS Number: 121524-09-2
Molecular Formula: C22H27Cl2NO4
Molecular Weight: 440.4 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
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Product Introduction

Description
Amibegron hydrochloride is a selective β3-adrenergic receptor agonist that has been studied for its potential therapeutic effects in various medical conditions. It is a chemical compound that has been synthesized and extracted using different methods. This paper aims to provide an overview of the methods of synthesis or extraction, chemical structure, biological activity, biological effects, applications, future perspectives, and challenges of Amibegron hydrochloride.
Applications in Various Fields
Amibegron hydrochloride has various applications in medical research, environmental research, and industrial research. In medical research, it has been studied for its role in drug development, clinical trials, and findings, benefits, and potential side effects. In environmental research, it has been studied for its effects on ecosystems, role in pollution management, sustainability, and environmental impact. In industrial research, it has been used in manufacturing processes to improve product quality and efficiency, and health and safety considerations.

Properties

CAS Number

121524-09-2

Product Name

Amibegron hydrochloride

IUPAC Name

ethyl 2-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]acetate;hydrochloride

Molecular Formula

C22H27Cl2NO4

Molecular Weight

440.4 g/mol

InChI

InChI=1S/C22H26ClNO4.ClH/c1-2-27-22(26)14-28-20-9-7-15-6-8-19(11-17(15)12-20)24-13-21(25)16-4-3-5-18(23)10-16;/h3-5,7,9-10,12,19,21,24-25H,2,6,8,11,13-14H2,1H3;1H/t19-,21-;/m0./s1

InChI Key

NQIZCDQCNYCVAS-RQBPZYBGSA-N

SMILES

CCOC(=O)COC1=CC2=C(CCC(C2)NCC(C3=CC(=CC=C3)Cl)O)C=C1.Cl

Synonyms

[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]ox]yacetic acid ethyl ester hydrochloride

Canonical SMILES

CCOC(=O)COC1=CC2=C(CCC(C2)NCC(C3=CC(=CC=C3)Cl)O)C=C1.Cl

Isomeric SMILES

CCOC(=O)COC1=CC2=C(CC[C@@H](C2)NC[C@@H](C3=CC(=CC=C3)Cl)O)C=C1.Cl
Method of Synthesis or Extraction
Amibegron hydrochloride can be synthesized using different methods, including chemical synthesis and enzymatic synthesis. Chemical synthesis involves the reaction of different chemical compounds to form Amibegron hydrochloride. Enzymatic synthesis, on the other hand, involves the use of enzymes to catalyze the reaction of different substrates to form Amibegron hydrochloride. The efficiency and yield of each method depend on various factors such as the purity of the starting materials, reaction conditions, and the type of catalyst used. Environmental and safety considerations are also important factors to consider when choosing a method of synthesis or extraction.
Chemical Structure and Biological Activity
The chemical structure of Amibegron hydrochloride consists of a pyridine ring, a phenyl ring, and a hydroxyl group. It is a selective β3-adrenergic receptor agonist that binds to the β3-adrenergic receptor and activates it. The mechanism of action of Amibegron hydrochloride involves the activation of the β3-adrenergic receptor, which leads to the activation of adenylate cyclase and the production of cyclic adenosine monophosphate (cAMP). This, in turn, leads to the activation of protein kinase A (PKA) and the phosphorylation of various proteins involved in cell function and signal transduction.
Biological Effects
Amibegron hydrochloride has been shown to have potential therapeutic effects in various medical conditions such as obesity, diabetes, and overactive bladder. It has been shown to improve insulin sensitivity, increase energy expenditure, and reduce body weight in animal models. However, it also has potential toxic effects such as increased heart rate and blood pressure, which need to be carefully monitored.
Future Perspectives and Challenges
The use and study of Amibegron hydrochloride are currently limited by various factors such as its potential toxic effects, lack of long-term safety data, and limited understanding of its mechanism of action. Possible solutions and improvements include the development of safer and more effective β3-adrenergic receptor agonists, the use of more advanced techniques to study its mechanism of action, and the conduct of more extensive clinical trials to determine its safety and efficacy. Future trends and prospects in the application of Amibegron hydrochloride in scientific research include the development of new therapeutic applications and the exploration of its potential in other medical conditions.
Conclusion:
Amibegron hydrochloride is a selective β3-adrenergic receptor agonist that has potential therapeutic effects in various medical conditions. It can be synthesized and extracted using different methods, and its chemical structure and biological activity have been extensively studied. However, its use and study are currently limited by various factors, and future research is needed to fully understand its potential therapeutic and toxic effects.

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