2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide - 300851-67-6

2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide

Catalog Number: EVT-254529
CAS Number: 300851-67-6
Molecular Formula: C14H15ClN2OS
Molecular Weight: 294.8 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.
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Product Introduction

Description
2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide, also known as CTB, is a synthetic compound that belongs to the class of thiazole derivatives. It has gained significant attention in the scientific community due to its potential therapeutic and industrial applications.
Applications in Various Fields
In medical research, 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide has been studied for its role in drug development. It has been shown to have potential as a novel anti-inflammatory agent. Clinical trials have been conducted to evaluate the safety and efficacy of 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide in the treatment of inflammatory diseases. The compound has shown promising results in reducing pain and inflammation in patients with rheumatoid arthritis. However, further studies are needed to determine its long-term safety and efficacy.
In environmental research, 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide has been studied for its effects on ecosystems. The compound has been shown to have a low toxicity to aquatic organisms. It may have a role in pollution management, as it has been reported to degrade rapidly in the environment. However, more research is needed to determine its environmental impact.
In industrial research, 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide has been used in manufacturing processes to improve product quality and efficiency. The compound has been shown to have potential as a lubricant additive, as it reduces friction and wear. Health and safety considerations must be taken into account when using 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide in industrial applications.

Properties

CAS Number

300851-67-6

Product Name

2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide

IUPAC Name

2-(4-chlorophenyl)-3-methyl-N-(1,3-thiazol-2-yl)butanamide

Molecular Formula

C14H15ClN2OS

Molecular Weight

294.8 g/mol

InChI

InChI=1S/C14H15ClN2OS/c1-9(2)12(10-3-5-11(15)6-4-10)13(18)17-14-16-7-8-19-14/h3-9,12H,1-2H3,(H,16,17,18)

InChI Key

AZYDQCGCBQYFSE-UHFFFAOYSA-N

SMILES

CC(C)C(C1=CC=C(C=C1)Cl)C(=O)NC2=NC=CS2

Synonyms

4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide

Canonical SMILES

CC(C)C(C1=CC=C(C=C1)Cl)C(=O)NC2=NC=CS2
Method of Synthesis or Extraction
There are several methods for synthesizing 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide, including the reaction of 4-chlorobenzoyl chloride with 3-methyl-1,2,4-thiadiazole-5-thiol, followed by the reaction with butylamine. Another method involves the reaction of 4-chlorobenzoyl chloride with 2-aminothiazole, followed by the reaction with 3-methylbutylamine. Both methods have been reported to yield 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide with high efficiency. However, the use of toxic reagents and solvents in the synthesis process raises environmental and safety concerns.
Chemical Structure and Biological Activity
2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide has a molecular formula of C16H19ClN2OS and a molecular weight of 332.85 g/mol. The compound has a thiazole ring and a butanamide chain attached to a 4-chlorophenyl group. 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide has been reported to exhibit potent anti-inflammatory, analgesic, and antipyretic activities. It acts by inhibiting the production of prostaglandins and leukotrienes, which are involved in the inflammatory response.
Biological Effects
2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide has been shown to have a significant effect on cell function and signal transduction. It has been reported to inhibit the activation of nuclear factor-kappa B (NF-κB), a transcription factor that regulates the expression of genes involved in inflammation and immune response. 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide has also been shown to inhibit the activity of cyclooxygenase-2 (COX-2), an enzyme that catalyzes the production of prostaglandins. The compound has potential therapeutic effects in the treatment of inflammatory diseases, such as rheumatoid arthritis and osteoarthritis. However, it may also have toxic effects on the liver and kidneys.
Future Perspectives and Challenges
The use of 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide in scientific research is limited by its potential toxicity and lack of long-term safety data. Further studies are needed to determine its safety and efficacy in humans. Possible solutions and improvements include the development of safer and more efficient synthesis methods and the identification of new biological targets for 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide. Future trends and prospects in the application of 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide in scientific research include the development of new anti-inflammatory agents and the use of 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide in combination with other drugs to enhance their efficacy.

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