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Niclosamide

Catalog Number: EVT-287919

CAS Number: 50-65-7

Molecular Formula: C13H8Cl2N2O4

Molecular Weight: 327.12 g/mol

The product is for non-human research only. Not for therapeutic or veterinary use.

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Product Introduction

Description

Niclosamide is a drug that has been used for decades to treat tapeworm infections in humans and animals. However, recent research has shown that it has potential therapeutic effects in a variety of diseases, including cancer, viral infections, and inflammatory disorders. This paper will discuss the methods of synthesis or extraction of niclosamide, its chemical structure and biological activity, its effects on cell function and signal transduction, its potential therapeutic and toxic effects, and its applications in medical, environmental, and industrial research.

Properties

CAS Number

50-65-7

Product Name

Niclosamide

IUPAC Name

5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

Molecular Formula

C13H8Cl2N2O4

Molecular Weight

327.12 g/mol

InChI

InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)

InChI Key

RJMUSRYZPJIFPJ-UHFFFAOYSA-N

SMILES

C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O

Solubility

1.6 mg/L (at 20 °C)
SPARINGLY SOL IN CHLOROFORM, ETHER, ETHANOL
SOL IN ACETONE
Sol at 20 °C in 150 parts of alcohol
In water = 5-8 mg/L at 20 °C
In water 1.6 (pH 6.4), 110 (pH 9.1) (both in mg/L, 20 °C)
Soluble in common organic solvents such as ethanol and diethyl ether.
Nearly insoluble in n-hexane, dichloromethane, 2-propanol, toluene
Niclosamide is almost insoluble in water; sparingly soluble in ethanol, chloroform, or ether; and soluble in acetone.

Synonyms

Bayer 2353
Bayer 73
Bayluscide
Clonitralide
Fenasal
Niclocide
Niclosamide
Niclosamide, 2-Aminoethanol (1:1)
Phenasal
Radewerm
Trédémine
Yomesan

Canonical SMILES

C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O

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