Atrial natriuretic factor (1-28) (human, porcine) - 91917-63-4

Atrial natriuretic factor (1-28) (human, porcine)

Catalog Number: EVT-242126
CAS Number: 91917-63-4
Molecular Formula: C127H205N45O39S3
Molecular Weight: 3082.5 g/mol
The product is for non-human research only. Not for therapeutic or veterinary use.

Product Introduction

Description
Atrial natriuretic factor (ANF) is a peptide hormone that is synthesized and secreted by the atria of the heart. ANF is involved in the regulation of blood pressure, fluid balance, and electrolyte homeostasis. The human and porcine forms of ANF consist of 28 amino acids and are commonly referred to as ANF (1-28).
Applications in Various Fields
Atrial natriuretic factor (1-28) (human, porcine) (1-28) has applications in medical research, environmental research, and industrial research. In medical research, Atrial natriuretic factor (1-28) (human, porcine) (1-28) has been studied for its role in drug development, clinical trials, and findings. Atrial natriuretic factor (1-28) (human, porcine) (1-28) has been shown to have beneficial effects on blood pressure, fluid balance, and electrolyte homeostasis in clinical trials. Potential side effects include hypotension, electrolyte imbalance, and renal dysfunction. In environmental research, Atrial natriuretic factor (1-28) (human, porcine) (1-28) has been studied for its effects on ecosystems, pollution management, and sustainability. Atrial natriuretic factor (1-28) (human, porcine) (1-28) has been shown to have potential as a biomarker for environmental stress and pollution. In industrial research, Atrial natriuretic factor (1-28) (human, porcine) (1-28) has been used in manufacturing processes to improve product quality and efficiency. Health and safety considerations include the handling and disposal of hazardous chemicals and waste.

Properties

CAS Number

91917-63-4

Product Name

Atrial natriuretic factor (1-28) (human, porcine)

IUPAC Name

4-[[1-[[1-[[2-[[1-[[5-amino-1-[[1-[[2-[[1-[[2-[[1-[[4-amino-1-[[1-[[1-[[5-carbamimidamido-1-[[1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[(2-amino-3-hydroxypropanoyl)amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoic acid

Molecular Formula

C127H205N45O39S3

Molecular Weight

3082.5 g/mol

InChI

InChI=1S/C127H205N45O39S3/c1-9-64(6)99(121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(60-212)119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)172-111(199)75(29-20-41-145-127(139)140)159-115(203)83(49-98(186)187)165-110(198)77(36-42-214-8)160-105(193)71(25-16-37-141-123(131)132)152-95(183)51-146-93(181)50-147-103(191)80(45-66-21-12-10-13-22-66)162-120(208)90(61-213)171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173/h10-15,21-24,30-33,62-65,70-90,99,173-178,212-213H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,201)(H,159,203)(H,160,193)(H,161,189)(H,162,208)(H,163,204)(H,164,207)(H,165,198)(H,166,195)(H,167,197)(H,168,196)(H,169,202)(H,170,205)(H,171,206)(H,172,199)(H,186,187)(H,210,211)(H4,131,132,141)(H4,133,134,142)(H4,135,136,143)(H4,137,138,144)(H4,139,140,145)

InChI Key

KGZJRXKGJRJKCB-UHFFFAOYSA-N

SMILES

CCC(C)C(C(=O)NCC(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CO)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)NC(=O)C(CCSC)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=CC=C3)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)N

Synonyms

Alternative Name: Atrial Natriuretic Peptide (1-28) (human, porcine)

Canonical SMILES

CCC(C)C(C(=O)NCC(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CO)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)NC(=O)C(CCSC)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=CC=C3)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)N
Method of Synthesis or Extraction
Atrial natriuretic factor (1-28) (human, porcine) (1-28) can be synthesized using solid-phase peptide synthesis (SPPS) or extracted from porcine atria. SPPS involves the stepwise addition of amino acids to a growing peptide chain on a solid support. The yield and efficiency of SPPS depend on the quality of the starting materials, the reaction conditions, and the purification methods used. Extraction of Atrial natriuretic factor (1-28) (human, porcine) (1-28) from porcine atria involves homogenization, acid extraction, and purification by chromatography. The yield and efficiency of extraction depend on the quality of the starting material, the extraction conditions, and the purification methods used. Environmental and safety considerations for both methods include the disposal of hazardous chemicals and waste.
Chemical Structure and Biological Activity
Atrial natriuretic factor (1-28) (human, porcine) (1-28) has a cyclic structure with a disulfide bond between cysteine residues at positions 7 and 23. The biological activity of Atrial natriuretic factor (1-28) (human, porcine) (1-28) is mediated by binding to the natriuretic peptide receptor A (NPR-A) on the surface of target cells. NPR-A is a transmembrane receptor that activates intracellular signaling pathways, leading to the production of cyclic guanosine monophosphate (cGMP). cGMP is a second messenger that regulates ion channels, enzymes, and transcription factors, resulting in the biological effects of Atrial natriuretic factor (1-28) (human, porcine) (1-28). Atrial natriuretic factor (1-28) (human, porcine) (1-28) has potent natriuretic, diuretic, and vasodilatory effects, which contribute to its role in the regulation of blood pressure, fluid balance, and electrolyte homeostasis.
Biological Effects
Atrial natriuretic factor (1-28) (human, porcine) (1-28) has a variety of biological effects on cell function and signal transduction. Atrial natriuretic factor (1-28) (human, porcine) (1-28) stimulates the production of cGMP, which activates protein kinase G (PKG) and regulates ion channels, enzymes, and transcription factors. Atrial natriuretic factor (1-28) (human, porcine) (1-28) also inhibits the production of aldosterone, a hormone that promotes sodium retention and potassium excretion. Atrial natriuretic factor (1-28) (human, porcine) (1-28) has potential therapeutic and toxic effects, depending on the dose and duration of exposure. Therapeutic effects include the treatment of hypertension, heart failure, and renal disease. Toxic effects include hypotension, electrolyte imbalance, and renal dysfunction.
Future Perspectives and Challenges
Current limitations in the use and study of Atrial natriuretic factor (1-28) (human, porcine) (1-28) include the need for improved methods of synthesis and extraction, the need for more specific and sensitive assays for Atrial natriuretic factor (1-28) (human, porcine) (1-28) and its metabolites, and the need for more comprehensive studies of the long-term effects of Atrial natriuretic factor (1-28) (human, porcine) (1-28) exposure. Possible solutions and improvements include the development of new methods of synthesis and extraction, the use of more specific and sensitive assays, and the conduct of more comprehensive studies. Future trends and prospects in the application of Atrial natriuretic factor (1-28) (human, porcine) (1-28) in scientific research include the development of new therapeutic agents, the identification of new biological targets, and the exploration of new applications in environmental and industrial research.

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