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Epitalon

Catalog Number: EVT-242214

CAS Number: 307297-39-8

Molecular Formula: C14H22N4O9

Molecular Weight: 390.35 g/mol

The product is for non-human research only. Not for therapeutic or veterinary use.

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Product Introduction

Description

Epitalon is a synthetic polypeptide called epithelial vitamin, which is identified as the putative active component of a bovine pineal gland extract known as epithalamin. Epitalon is a tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly. Epitalon decreases the age-related changes in immune and neuroendocrine systems, reduces the incidence of recurrent infections and chronic diseases. Epitalon appears to induce telomere elongation via increased telomerase activity in human somatic cells in vitro. Epitalon appears to inhibit the synthesis of the MMP9 protein in vitro in aging skin fibroblasts. Lower levels of DNA damage were observed in senescence-accelerated mice (SAMP-1) treated with epithalon. Several studies suggest that epithalon may cross the blood-brain barrier, where it may stimulate cortical neurons and increase levels of phosphor-CREB, a DNA-binding protein important in learning and memory.

Properties

CAS Number

307297-39-8

Product Name

Epitalon

IUPAC Name

(4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

Molecular Formula

C14H22N4O9

Molecular Weight

390.35 g/mol

InChI

InChI=1S/C14H22N4O9/c1-6(15)12(25)17-7(2-3-9(19)20)14(27)18-8(4-10(21)22)13(26)16-5-11(23)24/h6-8H,2-5,15H2,1H3,(H,16,26)(H,17,25)(H,18,27)(H,19,20)(H,21,22)(H,23,24)/t6-,7-,8-/m0/s1

InChI Key

HGHOBRRUMWJWCU-FXQIFTODSA-N

SMILES

CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NCC(=O)O)N

Synonyms

Ala-Glu-Asp-Gly; Epithalon; 307297-39-8; 64082-79-7; Epitalon; L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-glycine

Canonical SMILES

CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NCC(=O)O)N

Isomeric SMILES

C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O)N

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