N-Methyl-L-aspartic acid (NMDA) is a non-proteinogenic amino acid that acts as an agonist for the NMDA receptor, a subtype of glutamate receptor. It is a potent neurotoxin that can cause excitotoxicity, a process that leads to neuronal death. NMDA has been extensively studied for its role in various physiological and pathological processes, including learning and memory, synaptic plasticity, and neurodegenerative diseases. This paper aims to provide a comprehensive review of NMDA, including its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, and future perspectives and challenges.
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