Home > Products > Screening Compounds P61246 > Melphalan hydrochloride

Melphalan hydrochloride

Catalog Number: EVT-248152

CAS Number: 3223-07-2

Molecular Formula: C13H19Cl3N2O2

Molecular Weight: 305,21*36,45 g/mole

The product is for non-human research only. Not for therapeutic or veterinary use.

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Product Introduction

Description

Melphalan hydrochloride is a chemotherapy drug used to treat various types of cancer, including multiple myeloma, ovarian cancer, and breast cancer. It is a derivative of nitrogen mustard and belongs to the class of alkylating agents. Melphalan hydrochloride is a prodrug that is converted to its active form, melphalan, in the liver. This paper aims to provide a comprehensive review of melphalan hydrochloride, including its method of synthesis or extraction, chemical structure and biological activity, biological effects, applications, and future perspectives and challenges.

Properties

CAS Number

3223-07-2

Product Name

Melphalan hydrochloride

IUPAC Name

(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid;hydrochloride

Molecular Formula

C13H19Cl3N2O2

Molecular Weight

305,21*36,45 g/mole

InChI

InChI=1S/C13H18Cl2N2O2.ClH/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;/h1-4,12H,5-9,16H2,(H,18,19);1H/t12-;/m0./s1

InChI Key

OUUYBRCCFUEMLH-YDALLXLXSA-N

SMILES

C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl.Cl

Solubility

95% ethanol <0.9 (mg/mL)
10% aqueous ethanol 1.3 (mg/mL)
Methanol 2.8 - 5.6 (mg/mL)
Water 1.7 - 2.3 (mg/mL)
Chloroform <1 (mg/mL)
0.1NHCL 9-17 (mg/mL)
0.1 N NaOH 7-10.6 (mg/mL)
Acetone <1 (mg/mL)
pH 4 citrate buffer 2.2 - 2.6 (mg/mL)
pH 9 borate buffer 2.0 - 2.4 (mg/mL)

Synonyms

Melphalanhydrochloride;MelphalanHCl;3223-07-2;L-Sarcolysinehydrochloride;UNII-1VXP4V453T;Phenylalaninemustardhydrochloride;SK15673;Alkeranhydrochloride;L-Phenylalaninemustardhydrochloride;Melfalanhydrochloride;CB3025hydrochloride;Alaninenitrogenmustardhydrochloride;AI3-26377;WLN:QVYZ1RDN2G2G&GH;L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alaninemonohydrochloride;L-Alanine,3-(p-(bis(2-chloroethyl)amino)phenyl)-,hydrochloride;Alkeran(GlaxoSmith);ALANINE,3-(p-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-,MONOHYDROCHLORIDE,L-;L-Alanine,hydrochloride;SCHEMBL41335;1VXP4V453T;CHEMBL1200863;CTK8G0783;L-Phenylalanine,monohydrochloride;OUUYBRCCFUEMLH-YDALLXLXSA-N

Canonical SMILES

C1=CC(=CC=C1CC(C(=O)O)[NH3+])N(CCCl)CCCl.[Cl-]

Isomeric SMILES

C1=CC(=CC=C1C[C@@H](C(=O)O)[NH3+])N(CCCl)CCCl.[Cl-]

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