Recombinant HHLA2 Protein, Human (ECD, Fc Tag)
Recombinant Proteins
The human HHLA2 (NP_009003.1) (Met1-Asn344) was expressed with the Fc region of human IgG1 at the C-terminus
The recombinant human HHLA2 consists 560a.a and predicts a molecular weight of 63.7 kDa.
Formulation:
The recombinant human HHLA2 consists 560a.a and predicts a molecular weight of 63.7 kDa.
Source:
HEK293 Cells
Usage:
Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant HHLA2 Protein, Human (ECD, Fc Tag)
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog Number: BT-200015
Molecular Weight: The recombinant human HHLA2 consists 560a.a and predicts a molecular weight of 63.7 kDa.
Formulation: Recombinant HHLA2 Protein was lyophilized from sterile PBS, pH 7.4.1
Source: HEK293 Cells
| Product Name | Recombinant HHLA2 Protein, Human (ECD, Fc Tag) |
|---|---|
| Molecular Weight | The recombinant human HHLA2 consists 560a.a and predicts a molecular weight of 63.7 kDa. |
| AA Sequence | Met1-Asn344 |
| Bioactivity | 1.Measured by its binding ability in a functional ELISA. 2.Immobilized human TMIGD2 at 10ug/mL (100uL/well) can bind human HHLA2-Fc, the EC50 of human HHLA2-Fc is 0.3-3ug/mL. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method |
| Formulation | Recombinant HHLA2 Protein was lyophilized from sterile PBS, pH 7.4.1 |
| Host Species | Homo sapiens (Human) |
| Description | The human HHLA2 (NP_009003.1) (Met1-Asn344) was expressed with the Fc region of human IgG1 at the C-terminus |
| Product Background | B7H7 gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants.HERV–H LTR-associating 2 (HHLA2, also called B7H7/B7-H5/B7y)has been recently discovered as the newest member of the B7 family and has 23–33% similarity in amino acid sequence with the other B7 molecules. This ligand is the only B7 family member that is found in humans but not in mice. It is constitutively expressed on the surface of human monocytes and is induced on B cells. HHLA2 binds to its putative receptor(s) on a variety of immune cells including CD4 and CD8 T cells and antigen-presenting cells. Similarly to B7-H3, both a T cell coinhibitory role as well as a costimulatory role has been reported for this ligand.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy |
| Product Memo | B7-H7 Protein, Human;B7H7 Protein, Human;HHLA2 Protein, Human |
| Product Type | Recombinant Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Source | HEK293 Cells |
| Storage | Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Terminal | Ile 23 |
| Usage | Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use |
| Last Modified | Aug 20 2021 |