Recombinant ZIP Kinase Protein, Human (GST Tag) Recombinant Proteins The full length of human DAPK3 (NP_001339.1) (Met 1-Arg 454) was fused with the GST tag at the N-terminus The recombinant human DAPK3/GST chimera consists of 678a.a and predicts a molecular weight of 79 kDa. It migrates as an approximately 70 kDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human DAPK3/GST chimera consists of 678a.a and predicts a molecular weight of 79 kDa. It migrates as an approximately 70 kDa band in SDS-PAGE under reducing conditions.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant ZIP Kinase Protein, Human (GST Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog Number: BT-200018

Molecular Weight: The recombinant human DAPK3/GST chimera consists of 678a.a and predicts a molecular weight of 79 kDa. It migrates as an approximately 70 kDa band in SDS-PAGE under reducing conditions.

Formulation: Recombinant ZIP Kinase Proteinwas supplied as sterile 20mM Tris, 500mM NaCl, 10mM GSH, pH 7.41

Source: Baculovirus-Insect Cells

Product Name Recombinant ZIP Kinase Protein, Human (GST Tag)
Molecular Weight The recombinant human DAPK3/GST chimera consists of 678a.a and predicts a molecular weight of 79 kDa. It migrates as an approximately 70 kDa band in SDS-PAGE under reducing conditions.
AA Sequence Met 1-Arg 454
Bioactivity The specific activity was determined to be 5 nmol/min/mg using MBP as substrate.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant ZIP Kinase Proteinwas supplied as sterile 20mM Tris, 500mM NaCl, 10mM GSH, pH 7.41
Host Species Homo sapiens (Human)
Description The full length of human DAPK3 (NP_001339.1) (Met 1-Arg 454) was fused with the GST tag at the N-terminus
Product Background Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains oneprotein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. It also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. DAPK3 / ZIPK regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. It is involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.
Product Memo DLK Protein, Human;ZIP Protein, Human;ZIPK Protein, Human
Product Type Recombinant Protein
Purity Greater than 85% as determined by SDS-PAGE
Source Baculovirus-Insect Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Met
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Aug 20 2021