Recombinant XIAP Protein, Human (AVI Tag) Recombinant Proteins The human XIAP (NP_001158.2) (Leu 121-Thr 356) was fused with an AVI tag at the C-terminus, and additonal two amino acids (Gly & Pro) at the N-terminus The recombinant human XIAP comprises 253a.a and has a predicted molecular weight of 29.1 kDa as estimated in SDS-PAGE under non-reduced conditions.
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Formulation: The recombinant human XIAP comprises 253a.a and has a predicted molecular weight of 29.1 kDa as estimated in SDS-PAGE under non-reduced conditions.
Source: E. coli
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant XIAP Protein, Human (AVI Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-200074

Molecular Weight: The recombinant human XIAP comprises 253a.a and has a predicted molecular weight of 29.1 kDa as estimated in SDS-PAGE under non-reduced conditions.

Formulation: Recombinant XIAP Protein was lyophilized from sterile 25mM Tris, 10mM DTT, 1% glycerol, 0.2M Glutamine Potassium, pH 8.01

Source: E. coli

Product Name Recombinant XIAP Protein, Human (AVI Tag)
Molecular Weight The recombinant human XIAP comprises 253a.a and has a predicted molecular weight of 29.1 kDa as estimated in SDS-PAGE under non-reduced conditions.
AA Sequence Leu 121-Thr 356
Bioactivity Measured by its binding ability in a functional ELISA.Immobilized recombinant human SMAC-His can bind recombinant human XIAP-AVI with a linear range of 0.125-1.0 ug/ml.
Formulation Recombinant XIAP Protein was lyophilized from sterile 25mM Tris, 10mM DTT, 1% glycerol, 0.2M Glutamine Potassium, pH 8.01
Host Species Homo sapiens (Human)
Description The human XIAP (NP_001158.2) (Leu 121-Thr 356) was fused with an AVI tag at the C-terminus, and additonal two amino acids (Gly & Pro) at the N-terminus
Product Background E3 ubiquitin-protein ligase XIAP / BIRC4, also known as inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. XIAP / BIRC4 functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. XIAP / BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this encoding gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Thought to be the most potent apoptosis suppressor, XIAP / BIRC4, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several caspases, is up-regulated in a many tumour cell types. Defects in XIAP / BIRC4 are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2). XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
Product Memo API3 Protein, Human;BIRC4 Protein, Human;hIAP-3 Protein, Human;hIAP3 Protein, Human;IAP-3 Protein, Human;ILP1 Protein, Human;MIHA Protein, Human;XLP2 Protein, Human
Product Type Recombinant Protein
Purity Greater than 75% as determined by SDS-PAGE
Source E. coli
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Met
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Mar 08 2019