Recombinant XIAP Protein, Human (BIR3 domain, His Tag) Recombinant Proteins The human BIR3 domain of XIAP (NP_001158.2) (Asn252-Thr356) was expressed with a polyhistidine tag at the N-terminus The recombinant human BIR3 domain of XIAP consists of 123a.a and predicts a molecular weight of 14.3 KDa. It migrates as an approximately 14.8 KDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human BIR3 domain of XIAP consists of 123a.a and predicts a molecular weight of 14.3 KDa. It migrates as an approximately 14.8 KDa band in SDS-PAGE under reducing conditions.
Source: E. coli
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant XIAP Protein, Human (BIR3 domain, His Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-200075

Molecular Weight: The recombinant human BIR3 domain of XIAP consists of 123a.a and predicts a molecular weight of 14.3 KDa. It migrates as an approximately 14.8 KDa band in SDS-PAGE under reducing conditions.

Formulation: Recombinant XIAP Protein was lyophilized from sterile PBS, pH 7.4.1

Source: E. coli

Product Name Recombinant XIAP Protein, Human (BIR3 domain, His Tag)
Molecular Weight The recombinant human BIR3 domain of XIAP consists of 123a.a and predicts a molecular weight of 14.3 KDa. It migrates as an approximately 14.8 KDa band in SDS-PAGE under reducing conditions.
AA Sequence Asn252-Thr356
Bioactivity Please contact us for detailed information
Formulation Recombinant XIAP Protein was lyophilized from sterile PBS, pH 7.4.1
Host Species Homo sapiens (Human)
Description The human BIR3 domain of XIAP (NP_001158.2) (Asn252-Thr356) was expressed with a polyhistidine tag at the N-terminus
Product Background E3 ubiquitin-protein ligase XIAP / BIRC4, also known as inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, and IAP-like protein, is a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. XIAP / BIRC4 functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. XIAP / BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this encoding gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Thought to be the most potent apoptosis suppressor, XIAP / BIRC4, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several caspases, is up-regulated in a many tumour cell types. Defects in XIAP / BIRC4 are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2). XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
Product Memo API3 Protein, Human;BIRC4 Protein, Human;hIAP-3 Protein, Human;hIAP3 Protein, Human;IAP-3 Protein, Human;ILP1 Protein, Human;MIHA Protein, Human;XLP2 Protein, Human
Product Type Recombinant Protein
Purity Greater than 95% as determined by SDS-PAGE
Source E. coli
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal His
Uniprot No P29218
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Mar 08 2019