Recombinant YES1 Protein, Human (His & GST Tag) Recombinant Proteins The human YES1 (NP_005424.1) (Gly 2-Leu 543) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus The recombinant human YES1/GST chimera consists of 779a.a and has a calculated molecular weight of 88.5 kDa. It migrates as an approximately 75 kDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human YES1/GST chimera consists of 779a.a and has a calculated molecular weight of 88.5 kDa. It migrates as an approximately 75 kDa band in SDS-PAGE under reducing conditions.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant YES1 Protein, Human (His & GST Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-200080

Molecular Weight: The recombinant human YES1/GST chimera consists of 779a.a and has a calculated molecular weight of 88.5 kDa. It migrates as an approximately 75 kDa band in SDS-PAGE under reducing conditions.

Formulation: Recombinant YES1 ProteinSupplied as sterile 20mM Tris, 500mM NaCl, 10% gly, 0.5mM TCEP, pH 8.01

Source: Baculovirus-Insect Cells

Product Name Recombinant YES1 Protein, Human (His & GST Tag)
Molecular Weight The recombinant human YES1/GST chimera consists of 779a.a and has a calculated molecular weight of 88.5 kDa. It migrates as an approximately 75 kDa band in SDS-PAGE under reducing conditions.
AA Sequence Gly 2-Leu 543
Bioactivity The specific activity was determined to be 35 nmol/min/mg using Poly(Glu,Tyr) 4 1 as substrate.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant YES1 ProteinSupplied as sterile 20mM Tris, 500mM NaCl, 10% gly, 0.5mM TCEP, pH 8.01
Host Species Homo sapiens (Human)
Description The human YES1 (NP_005424.1) (Gly 2-Leu 543) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus
Product Background Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 / c-Yes contains oneprotein kinase domain, oneSH2 domain and oneSH3 domain. It is thought that the subcellular distribution of Src-family tyrosine kinases, including c-Yes binding to the cellular membrane, is membranous and/or cytoplasmic. YES1 / c-Yes protein tyrosine kinase is known to be related to malignant transformation. YES1 / c-Yes and c-Src are the two most closely related members of the Src family of nonreceptor tyrosine kinases. Although there is much evidence to support redundancy in signaling between these two kinases. YES1 / c-Yes promotes formation of the tight junction by phosphorylating occludin, while c-Src signaling downregulates occludin formation in a Raf-1 dependent manner. YES1 / c-Yes has tyrosine kinase activity. It promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating MCP / CD46.
Product Memo c-yes Protein, Human;HsT441 Protein, Human;P61-YES Protein, Human;Yes Protein, Human
Product Type Recombinant Protein
Purity Greater than 80% as determined by SDS-PAGE
Source Baculovirus-Insect Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Met
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Mar 08 2019