Recombinant TrkA Protein, Human (His & Fc Tag) Recombinant Proteins The human NTRK1 (NP_002520.2) extracellular domain (Met 1-Pro 382) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus The recombinant human NTRK1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 598a.a and has a predicted molecular weight of 66 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rh NTRK1/Fc monomer is approximately 85-95 kDa due to glycosylation.
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Formulation: The recombinant human NTRK1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 598a.a and has a predicted molecular weight of 66 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rh NTRK1/Fc monomer is approximately 85-95 kDa due to glycosylation.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant TrkA Protein, Human (His & Fc Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-200274

Molecular Weight: The recombinant human NTRK1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 598a.a and has a predicted molecular weight of 66 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rh NTRK1/Fc monomer is approximately 85-95 kDa due to glycosylation.

Formulation: Recombinant TrkA Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant TrkA Protein, Human (His & Fc Tag)
AA Sequence Met 1-Pro 382
Bioactivity Measured by its ability to inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.04-0.15 ug/ml in the presence of 10 ng/ml of recombinant human NGF.
Description The human NTRK1 (NP_002520.2) extracellular domain (Met 1-Pro 382) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant TrkA Protein was lyophilized from sterile PBS, pH 7.41
Host Species Homo sapiens (Human)
Molecular Weight The recombinant human NTRK1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 598a.a and has a predicted molecular weight of 66 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rh NTRK1/Fc monomer is approximately 85-95 kDa due to glycosylation.
Product Background TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Product Memo MTC Protein, Human;p140-TrkA Protein, Human;TRK Protein, Human;Trk-A Protein, Human;TRK1 Protein, Human;TRKA Protein, Human
Product Type Recombinant Protein
Purity Greater than 98% as determined by SDS-PAGE
Source HEK293 Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Ala 33
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use