Recombinant TMP21 Protein, Human (Fc Tag) Recombinant Proteins The human TMED10 (NP_006818.3) (Met1-Arg185) was expressed with the Fc region of mouse IgG1 at the C-terminus The recombinant human TMED10 consists 388a.a and predicts a molecular weight of 44 kDa.
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Formulation: The recombinant human TMED10 consists 388a.a and predicts a molecular weight of 44 kDa.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant TMP21 Protein, Human (Fc Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-200350

Molecular Weight: The recombinant human TMED10 consists 388a.a and predicts a molecular weight of 44 kDa.

Formulation: Recombinant TMP21 Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant TMP21 Protein, Human (Fc Tag)
Molecular Weight The recombinant human TMED10 consists 388a.a and predicts a molecular weight of 44 kDa.
AA Sequence Met1-Arg185
Bioactivity Please contact us for detailed information
Endotoxin < 1.0 EU per μg protein as determined by the LAL method
Formulation Recombinant TMP21 Protein was lyophilized from sterile PBS, pH 7.4.1
Host Species Homo sapiens (Human)
Description The human TMED10 (NP_006818.3) (Met1-Arg185) was expressed with the Fc region of mouse IgG1 at the C-terminus
Product Background TMED1 disrupts the complex formation between TGF-beta type I (also termed ALK5) and type II receptors (TbetaRII). Misexpression studies revealed that TMED1 attenuated TGF-beta-mediated signaling. A 2-amino acid-long region from Thr(91) to Glu(11) within the extracellular region of TMED1 was found to be crucial for TMED1 interaction with both ALK5 and TbetaRII. Synthetic peptides corresponding to this region inhibit both TGF-beta-induced Smad2 phosphorylation and Smad-dependent transcriptional reporter activity. In a xenograft cancer model, where previously TGF-beta was shown to elicit tumor-promoting effects, gain-of-function and loss-of-function studies for TMED1 revealed a decrease and increase in the tumor size, respectively. That TMED1 expression levels are the key determinant for efficiency of TGF-beta receptor complex formation and signaling.
Product Memo p23 Protein, Human;P24(DELTA) Protein, Human;S31I125 Protein, Human;S31III125 Protein, Human;Tmp-21-I Protein, Human;TMP21 Protein, Human
Product Type Recombinant Protein
Purity Greater than (61.4 + 28.2)% as determined by SDS-PAGE.
Source HEK293 Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Ile 32
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Mar 08 2019