Recombinant TNF beta Protein, Human Recombinant Proteins The mature form of human TNFβ (P01374) (Leu 35-Leu 205) was expressed and purified, with an initial Met at the N-terminus The recombinant human TNFβ comprises 172a.a and predicts a molecular weight of 18.8 kDa as estimated in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human TNFβ comprises 172a.a and predicts a molecular weight of 18.8 kDa as estimated in SDS-PAGE under reducing conditions.
Source: E. coli
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant TNF beta Protein, Human

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-200355

Molecular Weight: The recombinant human TNFβ comprises 172a.a and predicts a molecular weight of 18.8 kDa as estimated in SDS-PAGE under reducing conditions.

Formulation: Recombinant TNF beta Protein was lyophilized from sterile 50mM Tris, pH 8.01

Source: E. coli

Product Name Recombinant TNF beta Protein, Human
Molecular Weight The recombinant human TNFβ comprises 172a.a and predicts a molecular weight of 18.8 kDa as estimated in SDS-PAGE under reducing conditions.
AA Sequence Leu 35-Leu 205
Bioactivity Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D.The ED50 for this effect is typically 0.01-0.1 ng/mL.
Formulation Recombinant TNF beta Protein was lyophilized from sterile 50mM Tris, pH 8.01
Host Species Homo sapiens (Human)
Description The mature form of human TNFβ (P01374) (Leu 35-Leu 205) was expressed and purified, with an initial Met at the N-terminus
Product Background Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1 and TNFB, is a secreted protein which belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is a highly inducible, secreted, and exists as homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRSF3 / LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells. TNF-beta/TNFSF1/Lymphotoxin alpha forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1/Lymphotoxin alpha is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in TNF-beta/TNFSF1/Lymphotoxin alpha are a cause of susceptibility psoriatic arthritis which is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy.
Product Memo LT Protein, Human;TNFB Protein, Human;TNFSF1 Protein, Human
Product Type Recombinant Protein
Purity Greater than 97% as determined by SDS-PAGE
Source E. coli
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Met
Uniprot No P01374
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Mar 08 2019