Recombinant STIM1 Protein, Human (His Tag) Recombinant Proteins The human STIM1 (NP_003147.2) extracellular domain (Met 1-Asp 213) was expressed, with a polyhistidine tag at the C-terminus The recombinant human STIM1 consists of 202a.a and predictes a molecular weight of 23.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rh STIM1 is approximately 33-38 kDa due to glycosylation.
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Formulation: The recombinant human STIM1 consists of 202a.a and predictes a molecular weight of 23.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rh STIM1 is approximately 33-38 kDa due to glycosylation.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant STIM1 Protein, Human (His Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-200546

Molecular Weight: The recombinant human STIM1 consists of 202a.a and predictes a molecular weight of 23.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rh STIM1 is approximately 33-38 kDa due to glycosylation.

Formulation: Recombinant STIM1 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant STIM1 Protein, Human (His Tag)
Molecular Weight The recombinant human STIM1 consists of 202a.a and predictes a molecular weight of 23.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular weight of rh STIM1 is approximately 33-38 kDa due to glycosylation.
AA Sequence Met 1-Asp 213
Bioactivity Please contact us for detailed information
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant STIM1 Protein was lyophilized from sterile PBS, pH 7.41
Host Species Homo sapiens (Human)
Description The human STIM1 (NP_003147.2) extracellular domain (Met 1-Asp 213) was expressed, with a polyhistidine tag at the C-terminus
Product Background Stromal interaction molecule 1, also known as STIM1 and GOK, is a cell membrane, a single-pass type I membrane protein and a endoplasmic reticulum membrane protein. STIM1 / GOK is ubiquitously expressed in various human primary cells and tumor cell lines. It contains oneEF-hand domain and oneSAM (sterile alpha motif) domain. STIM1 / GOK plays a role in mediating Ca2+influx following depletion of intracellular Ca2+stores. It acts as Ca2+sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca2+depletion, STIM1 / GOK translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca2+release-activated Ca2+(CRAC) channel subunit, TMEM142A / ORAI1. Transfection of STIM1 / GOK into cells derived from a rhabdoid tumor and from a rhabdomyosarcoma that do not express detectable levels of STIM1 can induce cell death, suggesting a possible role in the control of rhabdomyosarcomas and rhabdoid tumors. Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) which is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels.
Product Memo D11S4896E Protein, Human;GOK Protein, Human;IMD10 Protein, Human;STRMK Protein, Human;TAM Protein, Human;TAM1 Protein, Human
Product Type Recombinant Protein
Purity Greater than 97% as determined by SDS-PAGE
Source HEK293 Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Leu 23
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use