Recombinant SPG21 Protein, Mouse (His & GST Tag) Recombinant Proteins The mouse SPG21 isoform 1 (Q9CQC8-1) (Met 1-Pro 308) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus The secreted recombinant mouse SPG21/GST chimera consists of 545a.a and has a calculated molecular weight of 62.8kDa. The recombinant protein migrates as an approximately 52 kDa band in SDS-PAGE under reducing conditions.
$ $99 In stock
Formulation: The secreted recombinant mouse SPG21/GST chimera consists of 545a.a and has a calculated molecular weight of 62.8kDa. The recombinant protein migrates as an approximately 52 kDa band in SDS-PAGE under reducing conditions.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant SPG21 Protein, Mouse (His & GST Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-200581

Molecular Weight: The secreted recombinant mouse SPG21/GST chimera consists of 545a.a and has a calculated molecular weight of 62.8kDa. The recombinant protein migrates as an approximately 52 kDa band in SDS-PAGE under reducing conditions.

Formulation: Recombinant SPG21 Protein was lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 3mM DTT, 10% glycerol1

Source: Baculovirus-Insect Cells

Product Name Recombinant SPG21 Protein, Mouse (His & GST Tag)
Molecular Weight The secreted recombinant mouse SPG21/GST chimera consists of 545a.a and has a calculated molecular weight of 62.8kDa. The recombinant protein migrates as an approximately 52 kDa band in SDS-PAGE under reducing conditions.
AA Sequence Met 1-Pro 308
Bioactivity Please contact us for detailed information
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant SPG21 Protein was lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 3mM DTT, 10% glycerol1
Host Species Mouse
Description The mouse SPG21 isoform 1 (Q9CQC8-1) (Met 1-Pro 308) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus
Product Background Spastic paraplegia 21 (SPG21), also known as acid Cluster Protein 33 (ACP33) and Mast syndrome protein, is a member of the AB hydrolase superfamily. Human SPG21 is a 38 amino acid residue protein widely expressed in all tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. SPG21 binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation via the noncatalytic alpha/beta hydrolase fold domain. SPG21 thus is proposed to play a role as a negative regulatory factor in CD4-dependent T-cell activation of CD4. Defects in SPG21 are the cause of spastic paraplegia autosomal recessive type 21, also known as Mast syndrome, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. SPG21 is also associated with dementia and other central nervous system abnormalities.
Product Memo ACP33 Protein, Mouse;BM-019 Protein, Mouse;C78576 Protein, Mouse;D9Wsu18e Protein, Mouse;GL010 Protein, Mouse;MAST Protein, Mouse
Product Type Recombinant Protein
Purity Greater than 90% as determined by SDS-PAGE
Source Baculovirus-Insect Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Met
Uniprot No Q9CQC8
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Mar 08 2019