Recombinant SPG3A Protein, Human (GST Tag) Recombinant Proteins The human SPG3A (NP_056999.2) (Met 1-Thr 447) was fused with the GST tag at the N-terminus The recombinant human SPG3A/GST chimera consists of 671a.a and and has a calculated molecular weight of 77 kDa. It migrates as an approximately 66 kDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human SPG3A/GST chimera consists of 671a.a and and has a calculated molecular weight of 77 kDa. It migrates as an approximately 66 kDa band in SDS-PAGE under reducing conditions.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant SPG3A Protein, Human (GST Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog No: bt-200584

Molecular Weight: The recombinant human SPG3A/GST chimera consists of 671a.a and and has a calculated molecular weight of 77 kDa. It migrates as an approximately 66 kDa band in SDS-PAGE under reducing conditions.

Formulation: Recombinant SPG3A Protein was lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM PMSF, 0.5mM EDTA, 0.5mM GSH, pH 8.01

Source: Baculovirus-Insect Cells

Product Name Recombinant SPG3A Protein, Human (GST Tag)
Molecular Weight The recombinant human SPG3A/GST chimera consists of 671a.a and and has a calculated molecular weight of 77 kDa. It migrates as an approximately 66 kDa band in SDS-PAGE under reducing conditions.
AA Sequence Met 1-Thr 447
Bioactivity Please contact us for detailed information
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant SPG3A Protein was lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM PMSF, 0.5mM EDTA, 0.5mM GSH, pH 8.01
Host Species Homo sapiens (Human)
Description The human SPG3A (NP_056999.2) (Met 1-Thr 447) was fused with the GST tag at the N-terminus
Product Background Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin subfamily. ATL1 / SPG3A is expressed predominantly in the adult and fetal central nervous system. Expression of ATL1 / SPG3A in adult brain is at least 5-fold higher than in other tissues. ATL1 / SPG3A is detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. ATL1 / SPG3A is also expressed in upper and lower motor neurons (at protein level). A distinguishing feature of ATL1 / SPG3A is its frequent early onset, raising the possibility that developmental abnormalities may be involved in its pathogenesis. Missense SPG3A mutant atlastin-1 proteins have impaired GTPase activity and may act in a dominant-negative, loss-of-function manner by forming mixed oligomers with wild-type atlastin-1. Defects in ATL1 / SPG3A are the cause of spastic paraplegia autosomal dominant type 3 (SPG3), also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
Product Memo AD-FSP Protein, Human;atlastin1 Protein, Human;FSP1 Protein, Human;GBP3 Protein, Human;HSN1D Protein, Human;SPG3 Protein, Human;SPG3A Protein, Human
Product Type Recombinant Protein
Purity Greater than 80% as determined by SDS-PAGE
Source Baculovirus-Insect Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Met
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Mar 08 2019