Recombinant ROBO4 Protein, Human (His Tag)
Recombinant Proteins
The human ROBO4 (Q8WZ75-1) N-terminal four domains (Met 1-Glu 469) was expressed, with a polyhistidine tag at the C-terminus
The recombinant human ROBO4 consists of 453a.a and has a calculated molecular weight of 49 kDa. As a result of glycosylation, it migrates as an approximately 55-60 kDa band in SDS-PAGE under reducing conditions.
Formulation:
The recombinant human ROBO4 consists of 453a.a and has a calculated molecular weight of 49 kDa. As a result of glycosylation, it migrates as an approximately 55-60 kDa band in SDS-PAGE under reducing conditions.
Source:
HEK293 Cells
Usage:
Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant ROBO4 Protein, Human (His Tag)
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog No: bt-200859
Molecular Weight: The recombinant human ROBO4 consists of 453a.a and has a calculated molecular weight of 49 kDa. As a result of glycosylation, it migrates as an approximately 55-60 kDa band in SDS-PAGE under reducing conditions.
Formulation: Recombinant ROBO4 Protein was lyophilized from sterile PBS, pH 7.4, 5% glycerol1
Source: HEK293 Cells
| Product Name | Recombinant ROBO4 Protein, Human (His Tag) |
|---|---|
| AA Sequence | Met 1-Glu 469 |
| Bioactivity | Please contact us for detailed information |
| Description | The human ROBO4 (Q8WZ75-1) N-terminal four domains (Met 1-Glu 469) was expressed, with a polyhistidine tag at the C-terminus |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Formulation | Recombinant ROBO4 Protein was lyophilized from sterile PBS, pH 7.4, 5% glycerol1 |
| Host Species | Homo sapiens (Human) |
| Molecular Weight | The recombinant human ROBO4 consists of 453a.a and has a calculated molecular weight of 49 kDa. As a result of glycosylation, it migrates as an approximately 55-60 kDa band in SDS-PAGE under reducing conditions. |
| Product Background | Roundabout homolog 4, also known as magic roundabout and ROBO4 is a member of theimmunoglobulin superfamily and ROBO family. ROBO4 is specifically expressed in endothelial cells. It is expressed at sites of angiogenesis in different tumor types. ROBO4 contains twofibronectin type-III domains and twoIg-like C2-type (immunoglobulin-like) domains. ROBO4 is the fourth identified member of the roundabout receptor family. It is the only Robo family member expressed in primary endothelial cells and that application of Slit inhibits their migration. ROBO4 is predominantly expressed in embryonic or tumor vascular endothelium and is considered important for vascular development and as a candidate tumor endothelial marker. ROBO4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development. ROBO4 is a receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO4 may mediate the inhibition of primary endothelial cell migration by Slit proteins. Activating ROBO4 may have broad therapeutic application in diseases characterized by excessive angiogenesis and/or vascular leak. |
| Product Memo | ECSM4 Protein, Human;MRB Protein, Human |
| Product Type | Recombinant Protein |
| Purity | Greater than 97% as determined by SDS-PAGE |
| Source | HEK293 Cells |
| Storage | Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Terminal | Gln 28 |
| Uniprot No | Q8WZ75 |
| Usage | Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use |