Recombinant OX40L Protein, Cynomolgus (Fc Tag)
Others
The cynomolgus TNFSF4 (F7FL80) (Gln51-Leu183) was expressed with the Fc region of mouse IgG1 at the N-terminus
The recombinant cynomolgus TNFSF4 is a disulfide-linked homodimer. The reduced monomer comprises 369a.a and has a calculated molecular weight of 42 KDa.The apparent molecular weight of it is approximately 48 KDa respectively in SDS-PAGE.
Formulation:
The recombinant cynomolgus TNFSF4 is a disulfide-linked homodimer. The reduced monomer comprises 369a.a and has a calculated molecular weight of 42 KDa.The apparent molecular weight of it is approximately 48 KDa respectively in SDS-PAGE.
Source:
HEK293 Cells
Usage:
Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant OX40L Protein, Cynomolgus (Fc Tag)
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog Number: BT-201291
Molecular Weight: The recombinant cynomolgus TNFSF4 is a disulfide-linked homodimer. The reduced monomer comprises 369a.a and has a calculated molecular weight of 42 KDa.The apparent molecular weight of it is approximately 48 KDa respectively in SDS-PAGE.
Formulation: Recombinant OX40L Protein was lyophilized from sterile PBS, pH 7.4.1
Source: HEK293 Cells
| Product Name | Recombinant OX40L Protein, Cynomolgus (Fc Tag) |
|---|---|
| Molecular Weight | The recombinant cynomolgus TNFSF4 is a disulfide-linked homodimer. The reduced monomer comprises 369a.a and has a calculated molecular weight of 42 KDa.The apparent molecular weight of it is approximately 48 KDa respectively in SDS-PAGE. |
| AA Sequence | Gln51-Leu183 |
| Bioactivity | Immobilized Cynomolgus mFc-TNFSF4 at 10 ug/ml (100 ul/well) can bind human TNFRSF4-Fch, The EC50 of human TNFRSF4-Fch is 0.23-0.55 ug/ml. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Formulation | Recombinant OX40L Protein was lyophilized from sterile PBS, pH 7.4.1 |
| Host Species | Cynomolgus |
| Description | The cynomolgus TNFSF4 (F7FL80) (Gln51-Leu183) was expressed with the Fc region of mouse IgG1 at the N-terminus |
| Product Background | OX-4L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-4L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-4L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.Immune CheckpointImmune Checkpoint TargetsCo-stimulatory Immune Checkpoint Targets ImmunotherapyCancer ImmunotherapyTargeted Therapy |
| Product Type | Recombinant Protein |
| Source | HEK293 Cells |
| Storage | Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Terminal | Asp |
| Uniprot No | F7FL80 |
| Usage | Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use |
| Last Modified | Jul 26 2021 |