Recombinant OXSR1 Protein, Human (GST Tag)
Others
The full length of human OXSR1 (NP_005100.1) (Met 1-Ser 527) was fused with the GST tag at the N-terminus
The recombinant human GST/OXSR1 chimera consists of 752a.a and predicts a molecular weight of 84 kDa. It migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.
Formulation:
The recombinant human GST/OXSR1 chimera consists of 752a.a and predicts a molecular weight of 84 kDa. It migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.
Source:
Baculovirus-Insect Cells
Usage:
Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant OXSR1 Protein, Human (GST Tag)
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog Number: BT-201297
Molecular Weight: The recombinant human GST/OXSR1 chimera consists of 752a.a and predicts a molecular weight of 84 kDa. It migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.
Formulation: Recombinant OXSR1 ProteinSupplied as sterile 50mM Tris, 100mM NaCl, pH 8.0, 0.5mM GSH, 0.5mM PMSF, 0.5mM EDTA, 10% glycerol1
Source: Baculovirus-Insect Cells
| Product Name | Recombinant OXSR1 Protein, Human (GST Tag) |
|---|---|
| Molecular Weight | The recombinant human GST/OXSR1 chimera consists of 752a.a and predicts a molecular weight of 84 kDa. It migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions. |
| AA Sequence | Met 1-Ser 527 |
| Bioactivity | Kinase activity untested |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Formulation | Recombinant OXSR1 ProteinSupplied as sterile 50mM Tris, 100mM NaCl, pH 8.0, 0.5mM GSH, 0.5mM PMSF, 0.5mM EDTA, 10% glycerol1 |
| Host Species | Homo sapiens (Human) |
| Description | The full length of human OXSR1 (NP_005100.1) (Met 1-Ser 527) was fused with the GST tag at the N-terminus |
| Product Background | Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39% identical to that of human SOK1. Of potential regulators surveyed, endogenous OXSR1 is activated only by osmotic stresses, notably sorbitol and to a lesser extent NaCl. OXSR1 did not increase the activity of coexpressed JNK, nor did it activate three other MAPKs, p38, ERK2, and ERK5. Phosphorylation by OXSR1 modulates the G protein sensitivity of PAK isoforms. The OXSR1 and SPAK are key enzymes in a signalling cascade regulating the activity of Na+/K+/2Cl- co-transporters (NKCCs) in response to osmotic stress. Both kinases have a conserved carboxy-terminal (CCT) domain, which recognizes a unique peptide (Arg-Phe-Xaa-Val) motif. The OXSR1 and SPAK kinases specifically recognize their upstream activators and downstream substrates. |
| Product Memo | OSR1 Protein, Human |
| Product Type | Recombinant Protein |
| Source | Baculovirus-Insect Cells |
| Storage | Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Terminal | Met |
| Usage | Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use |
| Last Modified | Jul 26 2021 |