Recombinant OXSR1 Protein, Human (GST Tag) Others The full length of human OXSR1 (NP_005100.1) (Met 1-Ser 527) was fused with the GST tag at the N-terminus The recombinant human GST/OXSR1 chimera consists of 752a.a and predicts a molecular weight of 84 kDa. It migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human GST/OXSR1 chimera consists of 752a.a and predicts a molecular weight of 84 kDa. It migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant OXSR1 Protein, Human (GST Tag) -

Recombinant OXSR1 Protein, Human (GST Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog Number: BT-201297

Molecular Weight: The recombinant human GST/OXSR1 chimera consists of 752a.a and predicts a molecular weight of 84 kDa. It migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.

Formulation: Recombinant OXSR1 ProteinSupplied as sterile 50mM Tris, 100mM NaCl, pH 8.0, 0.5mM GSH, 0.5mM PMSF, 0.5mM EDTA, 10% glycerol1

Source: Baculovirus-Insect Cells

Product Name Recombinant OXSR1 Protein, Human (GST Tag)
Molecular Weight The recombinant human GST/OXSR1 chimera consists of 752a.a and predicts a molecular weight of 84 kDa. It migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.
AA Sequence Met 1-Ser 527
Bioactivity Kinase activity untested
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant OXSR1 ProteinSupplied as sterile 50mM Tris, 100mM NaCl, pH 8.0, 0.5mM GSH, 0.5mM PMSF, 0.5mM EDTA, 10% glycerol1
Host Species Homo sapiens (Human)
Description The full length of human OXSR1 (NP_005100.1) (Met 1-Ser 527) was fused with the GST tag at the N-terminus
Product Background Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39% identical to that of human SOK1. Of potential regulators surveyed, endogenous OXSR1 is activated only by osmotic stresses, notably sorbitol and to a lesser extent NaCl. OXSR1 did not increase the activity of coexpressed JNK, nor did it activate three other MAPKs, p38, ERK2, and ERK5. Phosphorylation by OXSR1 modulates the G protein sensitivity of PAK isoforms. The OXSR1 and SPAK are key enzymes in a signalling cascade regulating the activity of Na+/K+/2Cl- co-transporters (NKCCs) in response to osmotic stress. Both kinases have a conserved carboxy-terminal (CCT) domain, which recognizes a unique peptide (Arg-Phe-Xaa-Val) motif. The OXSR1 and SPAK kinases specifically recognize their upstream activators and downstream substrates.
Product Memo OSR1 Protein, Human
Product Type Recombinant Protein
Source Baculovirus-Insect Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Met
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Jul 26 2021