Recombinant p38 Protein, Human (His Tag) Others The human MAPK14 isoform 2 (NP_620581.1) (Met1-Ser360) was fused with a polyhistide tag at the N-terminus The recombinant human MAPK14 consists of 378a.a and has a calculated molecular weight of 43.7 kDa. The recombinant protein migrates as an approximately 43 kDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human MAPK14 consists of 378a.a and has a calculated molecular weight of 43.7 kDa. The recombinant protein migrates as an approximately 43 kDa band in SDS-PAGE under reducing conditions.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant p38 Protein, Human (His Tag) -

Recombinant p38 Protein, Human (His Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog Number: BT-201298

Molecular Weight: The recombinant human MAPK14 consists of 378a.a and has a calculated molecular weight of 43.7 kDa. The recombinant protein migrates as an approximately 43 kDa band in SDS-PAGE under reducing conditions.

Formulation: Recombinant p38 ProteinSupplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly1

Source: Baculovirus-Insect Cells

Product Name Recombinant p38 Protein, Human (His Tag)
Molecular Weight The recombinant human MAPK14 consists of 378a.a and has a calculated molecular weight of 43.7 kDa. The recombinant protein migrates as an approximately 43 kDa band in SDS-PAGE under reducing conditions.
AA Sequence Met1-Ser360
Bioactivity Kinase activity untested
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant p38 ProteinSupplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly1
Host Species Homo sapiens (Human)
Description The human MAPK14 isoform 2 (NP_620581.1) (Met1-Ser360) was fused with a polyhistide tag at the N-terminus
Product Background MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK14 can be detected in brain, heart, placenta, pancreas and skeletal muscle and it is expressed to a lesser extent in lung, liver and kidney. MAPK14 is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with MAPK14. The substrates of p38 alpha include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of p38 alpha in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. In respond to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide, MAPK14 phosphorylates a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. MAPK14 plays a critical role in the production of some cytokines, for example IL-6. It may play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2.
Product Memo CSBP Protein, Human;CSBP1 Protein, Human;CSBP2 Protein, Human;CSPB1 Protein, Human;EXIP Protein, Human;Mxi2 Protein, Human;p38 Protein, Human;p38ALPHA Protein, Human;PRKM14 Protein, Human;PRKM15 Protein, Human;RK Protein, Human;SAPK2A Protein, Human
Product Type Recombinant Protein
Source Baculovirus-Insect Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal His
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Jul 26 2021