Recombinant p19 INK4d Protein, Human (GST Tag) Others The human CDKN2D (P55273) (Met 10Leu 166) was fused with the GST tag at the N-terminus The recombinant human CDKN2D/GST chimera consists of 400a.a and has a predicted molecular weight of 44.9 kDa. It migrates as an approxiamtely 46 kDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human CDKN2D/GST chimera consists of 400a.a and has a predicted molecular weight of 44.9 kDa. It migrates as an approxiamtely 46 kDa band in SDS-PAGE under reducing conditions.
Source: E. coli
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant p19 INK4d Protein, Human (GST Tag) -

Recombinant p19 INK4d Protein, Human (GST Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog Number: BT-201300

Molecular Weight: The recombinant human CDKN2D/GST chimera consists of 400a.a and has a predicted molecular weight of 44.9 kDa. It migrates as an approxiamtely 46 kDa band in SDS-PAGE under reducing conditions.

Formulation: Recombinant p19 INK4d Protein was lyophilized from sterile PBS, pH 7.51

Source: E. coli

Product Name Recombinant p19 INK4d Protein, Human (GST Tag)
Molecular Weight The recombinant human CDKN2D/GST chimera consists of 400a.a and has a predicted molecular weight of 44.9 kDa. It migrates as an approxiamtely 46 kDa band in SDS-PAGE under reducing conditions.
AA Sequence Met 10Leu 166
Bioactivity Immobilized human GST-CDKN2D at 10 ug/ml (100 ul/well) can bind biotinylated human GST-CDK4, The EC50 of biotinylated human GST-CDK4 is 0.52-1.2 ug/ml.
Formulation Recombinant p19 INK4d Protein was lyophilized from sterile PBS, pH 7.51
Host Species Homo sapiens (Human)
Description The human CDKN2D (P55273) (Met 10Leu 166) was fused with the GST tag at the N-terminus
Product Background Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product. It is clearly shown that DNA repair is the main target of p19ink4d effect and that diminished apoptosis is a downstream event. Experiments has uncovered a role of p19INK4d as a regulator of DNA-damage-induced apoptosis and suggest that it protects cells from undergoing apoptosis by allowing a more efficient DNA repair. It has been demonstrated that p19INK4d expression enhances cell survival under genotoxic conditions. Previous work has shown that inactivation of the cyclin-dependent kinase inhibitor (CKI) p19(Ink4d) leads to progressive hearing loss attributable to inappropriate DNA replication and subsequent apoptosis of hair cells. It may also involved in male reproductive function including testicular atrophy, alteration in serum follicle stimulating hormone, qualitative increase in germ cell apoptosis, and delayed kinetics of meiotic prophase markers.
Product Memo INK4D Protein, Human;p19 Protein, Human;p19-INK4D Protein, Human
Product Type Recombinant Protein
Source E. coli
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Met
Uniprot No P55273
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Jul 26 2021