Recombinant OPALIN Protein, Human (Fc Tag) Others The human OPALIN (Q96PE5-2) (Thr51-Glu141) was expressed with the Fc region of mouse IgG1 at the N-terminus The recombinant human OPALIN/mFc comprises 327a.a and has a predicted molecular weight of 37.4 kDa. The apparent molecular weight of the monomer is approximately 44 and 33 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Formulation: The recombinant human OPALIN/mFc comprises 327a.a and has a predicted molecular weight of 37.4 kDa. The apparent molecular weight of the monomer is approximately 44 and 33 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant OPALIN Protein, Human (Fc Tag) -

Recombinant OPALIN Protein, Human (Fc Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog Number: BT-201303

Molecular Weight: The recombinant human OPALIN/mFc comprises 327a.a and has a predicted molecular weight of 37.4 kDa. The apparent molecular weight of the monomer is approximately 44 and 33 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Recombinant OPALIN Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant OPALIN Protein, Human (Fc Tag)
Molecular Weight The recombinant human OPALIN/mFc comprises 327a.a and has a predicted molecular weight of 37.4 kDa. The apparent molecular weight of the monomer is approximately 44 and 33 kDa in SDS-PAGE under reducing conditions due to glycosylation.
AA Sequence Thr51-Glu141
Bioactivity Please contact us for detailed information
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant OPALIN Protein was lyophilized from sterile PBS, pH 7.41
Host Species Homo sapiens (Human)
Description The human OPALIN (Q96PE5-2) (Thr51-Glu141) was expressed with the Fc region of mouse IgG1 at the N-terminus
Product Background Opalin, or oligodendrocytic myelin paranodal and inner loop protein, is a transmembrane protein detected specifically in mammalian oligodendrocytes, and may play significant role in oligodendrocyte differentiation and myelination.Opalin has binding sites for Myt1 and cAMP-response element binding protein (CREB). Over-expression of Myt1, treatment of the cell with leukemia inhibitory factor (LIF), and cAMP analog (CREB activator) enhanced the expression of endogenous Opalin in Oli-neu cells and activated the oligodendrocyte enhancer. Thus LIF, cAMP signaling cascades and Myt1 may play significant roles in the differentiation of oligodendrocytes through their action on the Opalin oligodendrocyte enhancer. Enzymatic deglycosylation showed that myelin Opalin contained N- and O-glycans, and that the O-glycans, at least, had negatively charged sialic acids. Site-directed mutations at the glycan sites impaired the cell surface localization of Opalin. In addition to the somata and processes of oligodendrocytes, Opalin immunoreactivity was observed in myelinated axons in a spiral fashion, and was concentrated in the paranodal loop region. Immunogold electron microscopy demonstrated that Opalin was localized at particular sites in the paranodal loop membrane. These results suggest a role for highly sialylglycosylated Opalin in an intermembranous function of the myelin paranodal loops in the central nervous system.
Product Memo HTMP10 Protein, Human;OPALIN Protein, Human;TMEM10 Protein, Human;TMP10 Protein, Human
Product Type Recombinant Protein
Source HEK293 Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Asp
Uniprot No Q96PE5
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Jul 26 2021