Recombinant OSMR Protein, Human (His Tag)
Others
The human OSMR (NP_003990.1) extracellular domain (Met 1-Met 740) was expressed, fused with a polyhistidine tag at the C-terminus
The secreted recombinant human OSMR comprises 724a.a and has a predicted molecular weight of 82.6 kDa. As a result of glycosylation, rh OSMR migrates as an approximately 130-140 kDa band in SDS-PAGE under reducing conditions.
Formulation:
The secreted recombinant human OSMR comprises 724a.a and has a predicted molecular weight of 82.6 kDa. As a result of glycosylation, rh OSMR migrates as an approximately 130-140 kDa band in SDS-PAGE under reducing conditions.
Source:
HEK293 Cells
Usage:
Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant OSMR Protein, Human (His Tag)
The product is for non-human research only. Not for therapeutic or veterinary use.
Catalog Number: BT-201311
Molecular Weight: The secreted recombinant human OSMR comprises 724a.a and has a predicted molecular weight of 82.6 kDa. As a result of glycosylation, rh OSMR migrates as an approximately 130-140 kDa band in SDS-PAGE under reducing conditions.
Formulation: Recombinant OSMR Protein was lyophilized from sterile PBS, pH 7.41
Source: HEK293 Cells
| Product Name | Recombinant OSMR Protein, Human (His Tag) |
|---|---|
| Molecular Weight | The secreted recombinant human OSMR comprises 724a.a and has a predicted molecular weight of 82.6 kDa. As a result of glycosylation, rh OSMR migrates as an approximately 130-140 kDa band in SDS-PAGE under reducing conditions. |
| AA Sequence | Met 1-Met 740 |
| Bioactivity | Please contact us for detailed information |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Formulation | Recombinant OSMR Protein was lyophilized from sterile PBS, pH 7.41 |
| Host Species | Homo sapiens (Human) |
| Description | The human OSMR (NP_003990.1) extracellular domain (Met 1-Met 740) was expressed, fused with a polyhistidine tag at the C-terminus |
| Product Background | Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. |
| Product Memo | IL-31RB Protein, Human;OSMRB Protein, Human;PLCA1 Protein, Human |
| Product Type | Recombinant Protein |
| Source | HEK293 Cells |
| Storage | Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Terminal | Glu 28 |
| Usage | Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use |
| Last Modified | Jul 26 2021 |