Recombinant OSTM1 Protein, Mouse (His Tag) Others The mouse Ostm1 (NP_766004.1) (Met1-Ser288) was expressed with a polyhistidine tag at the C-terminus The recombinant mouse Ostm1 consists of 265a.a and predicts a molecular weight of 29.7 kDa.
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Formulation: The recombinant mouse Ostm1 consists of 265a.a and predicts a molecular weight of 29.7 kDa.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Recombinant OSTM1 Protein, Mouse (His Tag) -

Recombinant OSTM1 Protein, Mouse (His Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog Number: BT-201319

Molecular Weight: The recombinant mouse Ostm1 consists of 265a.a and predicts a molecular weight of 29.7 kDa.

Formulation: Recombinant OSTM1 Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant OSTM1 Protein, Mouse (His Tag)
Molecular Weight The recombinant mouse Ostm1 consists of 265a.a and predicts a molecular weight of 29.7 kDa.
AA Sequence Met1-Ser288
Bioactivity Please contact us for detailed information
Endotoxin < 1.0 EU per μg protein as determined by the LAL method
Formulation Recombinant OSTM1 Protein was lyophilized from sterile PBS, pH 7.4.1
Host Species Mouse
Description The mouse Ostm1 (NP_766004.1) (Met1-Ser288) was expressed with a polyhistidine tag at the C-terminus
Product Background Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. The researches found that OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has a important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrotic phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO).
Product Memo 1200002H13Rik Protein, Mouse;gl Protein, Mouse;HSPC019 Protein, Mouse
Product Type Recombinant Protein
Source HEK293 Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Ala 35
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Jul 26 2021