Recombinant M-CSF Protein, Human (His Tag) Recombinant Proteins The human CSF1 (NP_757349.1) (Met1-Arg255) was expressed with a polyhistidine tag at the C-terminus The recombinant human CSF1 consists 234a.a and predicts a molecular weight of 26.6 kDa.
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Formulation: The recombinant human CSF1 consists 234a.a and predicts a molecular weight of 26.6 kDa.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant M-CSF Protein, Human (His Tag)

Formulation: Recombinant M-CSF Protein was lyophilized from sterile PBS, pH 7.4.1

Source: HEK293 Cells

Product Name Recombinant M-CSF Protein, Human (His Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant M-CSF Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant human CSF1 consists 234a.a and predicts a molecular weight of 26.6 kDa.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method
Purity Greater than 95% as determined by SDS-PAGE.
Description The human CSF1 (NP_757349.1) (Met1-Arg255) was expressed with a polyhistidine tag at the C-terminus
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Arg255
Product Background Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.
Memo CSF-1 Protein, Human;M-CSF Protein, Human;MCSF Protein, Human
Terminal Glu 33
Bioactivity Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells.The ED50 for this effect is typically 2-8.1 ng/mL.