Recombinant MDMX Protein, Human (His Tag) Recombinant Proteins The human MDM4 (NP_002384.2) (Met1-Asp134) was expressed with a polyhistidine tag at the N-terminus The recombinant human MDM4 consists of 152a.a and predicts a molecular weight of 17 KDa. It migrates as an approximately 19.4 KDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human MDM4 consists of 152a.a and predicts a molecular weight of 17 KDa. It migrates as an approximately 19.4 KDa band in SDS-PAGE under reducing conditions.
Source: E. coli
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant MDMX Protein, Human (His Tag)

Formulation: Recombinant MDMX Protein was lyophilized from sterile PBS, pH 7.4.1

Source: E. coli

Product Name Recombinant MDMX Protein, Human (His Tag)
Product Type Recombinant Protein
Source E. coli
Formulation Recombinant MDMX Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant human MDM4 consists of 152a.a and predicts a molecular weight of 17 KDa. It migrates as an approximately 19.4 KDa band in SDS-PAGE under reducing conditions.
Purity Greater than 90% as determined by SDS-PAGE
Description The human MDM4 (NP_002384.2) (Met1-Asp134) was expressed with a polyhistidine tag at the N-terminus
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Asp134
Product Background MDM4 (also called MDMX) is a promising target for cancer therapy, as it is undetectable in most normal adult tissues but often upregulated in cancer cells to dampen p53 tumor-suppressor function.MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53.MDM4 is a key regulator of p53, whose biological activities depend on both transcriptional activity and transcription-independent mitochondrial functions. MDM4 binds to p53 and blocks its transcriptional activity. MDM4 is a negative regulator of p53 and cooperates with MDM2 in the cellular response to DNA damage.
Memo HDMX Protein, Human;MDMX Protein, Human;MRP1 Protein, Human
Terminal His
Bioactivity Please contact us for detailed information