Recombinant Meprin alpha Protein, Human (His Tag) Recombinant Proteins The human MEP1A (NP_005579.2) extracellular domain (Met 1-Gln 601) was expressed, fused with a polyhistidine tag at the C-terminus The secreted recombinant human MEP1A (pro form) consists of 591a.a with the predicted molecular weight of 67.7 kDa. As a result of glycosylation, rh MEP1A migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.
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Formulation: The secreted recombinant human MEP1A (pro form) consists of 591a.a with the predicted molecular weight of 67.7 kDa. As a result of glycosylation, rh MEP1A migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant Meprin alpha Protein, Human (His Tag)

Formulation: Recombinant Meprin alpha Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant Meprin alpha Protein, Human (His Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant Meprin alpha Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The secreted recombinant human MEP1A (pro form) consists of 591a.a with the predicted molecular weight of 67.7 kDa. As a result of glycosylation, rh MEP1A migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 90% as determined by SDS-PAGE
Description The human MEP1A (NP_005579.2) extracellular domain (Met 1-Gln 601) was expressed, fused with a polyhistidine tag at the C-terminus
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met 1-Gln 601
Product Background Meprin A subunit alpha, also known as MEP1A, and Endopeptidase-2, is a single-pass type I membrane protein which belongs to thepeptidase M12A family. MEP1A contains oneEGF-like domain, oneMAM domain, and oneMATH domain. Meprins are unique plasma membrane and secreted metalloproteinases that are highly regulated at the transcriptional and post-translational levels. Meprin alpha and beta subunits are abundantly expressed in kidney and intestinal epithelial cells, are secreted into the urinary tract and intestinal lumen, and are found in leukocytes and cancer cells under certain conditions. Meprins are capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. Meprin A and B are highly regulated, secreted and cell-surface homo- and hetero-oligomeric enzymes. Meprins are abundantly expressed in kidney and intestine. The multidomain alpha and beta subunits have high sequence identity. They have very different substrate specificities, oligomerization potentials and are differentially regulated. Meprin A appears to be an important therapeutic target and urinary excretion appears to be a potential biomarker of acute kidney injury ( AKI ).
Memo PPHA Protein, Human
Terminal Val 22
Bioactivity Please contact us for detailed information