Recombinant Kallikrein 7 Protein, Mouse (His Tag) Recombinant Proteins The mouse KLK7 (Q91VE3) (Met1-Arg249) was expressed with a C-terminal polyhistidine tag The recombinant mouse KLK7 comprises 239a.a and has a predicted molecular weight of 26.5 kDa. The apparent molecular weight of the protein is approximately 31 and 34 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Formulation: The recombinant mouse KLK7 comprises 239a.a and has a predicted molecular weight of 26.5 kDa. The apparent molecular weight of the protein is approximately 31 and 34 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant Kallikrein 7 Protein, Mouse (His Tag)

Formulation: Recombinant Kallikrein 7 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant Kallikrein 7 Protein, Mouse (His Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant Kallikrein 7 Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The recombinant mouse KLK7 comprises 239a.a and has a predicted molecular weight of 26.5 kDa. The apparent molecular weight of the protein is approximately 31 and 34 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than (71.4+26)% as determined by SDS-PAGE
Description The mouse KLK7 (Q91VE3) (Met1-Arg249) was expressed with a C-terminal polyhistidine tag
Host Species Mouse
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Met1-Arg249
Product Background Kallikrein-7, also known as kallikrein-related peptidase 7, Stratum corneum chymotryptic enzyme, Serine protease 6, KLK7, and PRSS6, is a secreted protein which belongs to thepeptidase S1 family and Kallikrein subfamily. Members of the Kallikrein family are involved in various malignancies such as prostate (PSA, KLK2, KLK15), ovarian (KLK4, KLK5, KLK6, KLK8, KLK1), and breast cancer (KLK1, KLK13, KLK14). Kallikrein-7 / KLK7 appears to be increased in ovarian cancer and higher KLK7 expression in ovarian cancer tissue is associated with poorer prognosis of ovarian cancer patients. Kallikrein-7 / KLK7 is abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Kallikrein-7 / KLK7 is up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at the protein level). It was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). Kallikrein-7 / KLK7 may catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. KLK7 also plays a role in the activation of precursors to inflammatory cytokines.
Memo Prss6 Protein, Mouse;SCCE Protein, Mouse
Uniprot Number Q91VE3
Terminal Gln 22
Bioactivity Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (AnaSpec, Cat#27114).The specific activity is >70 pmoles/min/ug.(Activation description The proenzyme needs to be activated by Thermolysin for an activated form)