Recombinant IL1RA Protein, Human (Fc Tag) Recombinant Proteins The mature form of human IL1RA (NP_776214.1) (Arg 26-Glu 177) was fused with the Fc region of human IgG1 at the N-terminus The recombinant human IL1RA/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 389a.a and predicts a molecular weight of 43.8 kDa. As a result of glycosylation, the rh IL1RA/Fc monomer migrates as approximately 45-55 kDa band in SDS-PAGE under reducing conditions.
$ $99 In stock
Formulation: The recombinant human IL1RA/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 389a.a and predicts a molecular weight of 43.8 kDa. As a result of glycosylation, the rh IL1RA/Fc monomer migrates as approximately 45-55 kDa band in SDS-PAGE under reducing conditions.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant IL1RA Protein, Human (Fc Tag)

The product is for non-human research only. Not for therapeutic or veterinary use.

Catalog Number: BT-202100

Molecular Weight: The recombinant human IL1RA/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 389a.a and predicts a molecular weight of 43.8 kDa. As a result of glycosylation, the rh IL1RA/Fc monomer migrates as approximately 45-55 kDa band in SDS-PAGE under reducing conditions.

Formulation: Recombinant IL1RA Protein was lyophilized from sterile PBS, pH 7.21

Source: HEK293 Cells

Product Name Recombinant IL1RA Protein, Human (Fc Tag)
Molecular Weight The recombinant human IL1RA/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 389a.a and predicts a molecular weight of 43.8 kDa. As a result of glycosylation, the rh IL1RA/Fc monomer migrates as approximately 45-55 kDa band in SDS-PAGE under reducing conditions.
AA Sequence Arg 26-Glu 177
Bioactivity Please contact us for detailed information
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Formulation Recombinant IL1RA Protein was lyophilized from sterile PBS, pH 7.21
Host Species Homo sapiens (Human)
Description The mature form of human IL1RA (NP_776214.1) (Arg 26-Glu 177) was fused with the Fc region of human IgG1 at the N-terminus
Product Background Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein encoding gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth.
Product Memo DIRA Protein, Human;ICIL-1RA Protein, Human;IL-1ra Protein, Human;IL-1ra3 Protein, Human;IL-1RN Protein, Human;IL1F3 Protein, Human;IL1RA Protein, Human;IRAP Protein, Human;MVCD4 Protein, Human
Product Type Recombinant Protein
Purity Greater than 98% as determined by SDS-PAGE
Source HEK293 Cells
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Terminal Glu 20
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Last Modified Aug 20 2021