Recombinant IL17 Protein, Human (His Tag) Recombinant Proteins The mature form of human IL17A (Q16552) (Gly24-Ala155) was expressed, with a polyhistidine tag at the N-terminus The recombinant human human IL17A consists of 152a.a and predicts a molecular weight of 17.3 KDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant human human IL17A consists of 152a.a and predicts a molecular weight of 17.3 KDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant IL17 Protein, Human (His Tag)

Formulation: Recombinant IL17 Protein was lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.41

Source: Baculovirus-Insect Cells

Product Name Recombinant IL17 Protein, Human (His Tag)
Product Type Recombinant Protein
Source Baculovirus-Insect Cells
Formulation Recombinant IL17 Protein was lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.41
Molecular Weight The recombinant human human IL17A consists of 152a.a and predicts a molecular weight of 17.3 KDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 98% as determined by SDS-PAGE
Description The mature form of human IL17A (Q16552) (Gly24-Ala155) was expressed, with a polyhistidine tag at the N-terminus
Host Species Homo sapiens (Human)
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Gly24-Ala155
Product Background IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Memo CTLA-8 Protein, Human;CTLA8 Protein, Human;IL-17 Protein, Human;IL-17A Protein, Human;IL17 Protein, Human
Uniprot Number Q16552
Terminal His
Bioactivity Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells in the presense of 20 ng/mL TNFα. The ED50 for this effect is 0.5-2.5 ng/mL.