Recombinant IL17 Protein, Marmoset Recombinant Proteins The Marmoset IL17A (ABQ09496.1) (Ile20-Ala155) was expressed and purified with an initial Met The recombinant Marmoset IL17A consists of 135a.a and has a calculated molecular weight of 15.4 kDa. It migrates as an 17 kDa band in SDS-PAGE under reducing conditions.
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Formulation: The recombinant Marmoset IL17A consists of 135a.a and has a calculated molecular weight of 15.4 kDa. It migrates as an 17 kDa band in SDS-PAGE under reducing conditions.
Source: E. coli
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant IL17 Protein, Marmoset

Formulation: Recombinant IL17 Protein was lyophilized from sterile PBS, pH 7.4.1

Source: E. coli

Product Name Recombinant IL17 Protein, Marmoset
Product Type Recombinant Protein
Source E. coli
Formulation Recombinant IL17 Protein was lyophilized from sterile PBS, pH 7.4.1
Molecular Weight The recombinant Marmoset IL17A consists of 135a.a and has a calculated molecular weight of 15.4 kDa. It migrates as an 17 kDa band in SDS-PAGE under reducing conditions.
Purity Greater than 85% as determined by SDS-PAGE
Description The Marmoset IL17A (ABQ09496.1) (Ile20-Ala155) was expressed and purified with an initial Met
Host Species Marmoset
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Ile20-Ala155
Product Background IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Terminal Met
Bioactivity 1. Measured by its binding ability in a functional ELISA. Immobilized Marmoset IL17A at 10 ug/mL (100 ul/well) can bind human IL17Ra, The EC50 of human IL17Ra is 8.5-20.0 ng/mL.2. Measured by its ability to induce IL-6 secretion by HFF human foreskin fibroblast cells.The ED50 for this effect is typically 2.95-11.8 ng/mL.