Recombinant IL17 Protein, Rabbit (His Tag) Recombinant Proteins The rabbit IL17A (XP_002714544.1) (Gly24-Ala153) was expressed with a polyhistidine tag at the N-terminus The recombinant rabbit IL17A consists 149a.a and predicts a molecular weight of 17.3 kDa.
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Formulation: The recombinant rabbit IL17A consists 149a.a and predicts a molecular weight of 17.3 kDa.
Source: Baculovirus-Insect Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant IL17 Protein, Rabbit (His Tag)

Formulation: Recombinant IL17 Protein was lyophilized from sterile was lyophilized from sterile 20 mM PBS, 500 mM NaCl, 10 % glycerol, pH 7.0.1

Source: Baculovirus-Insect Cells

Product Name Recombinant IL17 Protein, Rabbit (His Tag)
Product Type Recombinant Protein
Source Baculovirus-Insect Cells
Formulation Recombinant IL17 Protein was lyophilized from sterile was lyophilized from sterile 20 mM PBS, 500 mM NaCl, 10 % glycerol, pH 7.0.1
Molecular Weight The recombinant rabbit IL17A consists 149a.a and predicts a molecular weight of 17.3 kDa.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method
Purity Greater than 85% as determined by SDS-PAGE.
Description The rabbit IL17A (XP_002714544.1) (Gly24-Ala153) was expressed with a polyhistidine tag at the N-terminus
Host Species Rabbit
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Gly24-Ala153
Product Background IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Terminal His
Bioactivity 1.Measured by its binding ability in a functional ELISA. 2.Immobilized rabbit IL17a-His(Cat 65006-T07B) at 10ug/mL (100uL/well) can bind rat IL17RA-Fc3 ,the EC50 of rat IL17RA-Fc3 is 1-40 ng/mL.