Recombinant IL-13 Protein, Cynomolgus (His Tag) Recombinant Proteins The mature form of Cynomolgus (Macaca fascicularis) IL-13 (ABG75889.1) (Ser 21-Asn 132) was fused with a polyhistidine tag at the N-terminus The recombinant cynomolgus IL13 consists of 128a.a and has a calculated molecular weight of 14.5 kDa. The apparent molecular weight of the protein is approximately 25-35 kDa in SDS-PAGE under reducing conditions.
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Formulation: The recombinant cynomolgus IL13 consists of 128a.a and has a calculated molecular weight of 14.5 kDa. The apparent molecular weight of the protein is approximately 25-35 kDa in SDS-PAGE under reducing conditions.
Source: HEK293 Cells
Usage: Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use

Recombinant IL-13 Protein, Cynomolgus (His Tag)

Formulation: Recombinant IL-13 Protein was lyophilized from sterile PBS, pH 7.41

Source: HEK293 Cells

Product Name Recombinant IL-13 Protein, Cynomolgus (His Tag)
Product Type Recombinant Protein
Source HEK293 Cells
Formulation Recombinant IL-13 Protein was lyophilized from sterile PBS, pH 7.41
Molecular Weight The recombinant cynomolgus IL13 consists of 128a.a and has a calculated molecular weight of 14.5 kDa. The apparent molecular weight of the protein is approximately 25-35 kDa in SDS-PAGE under reducing conditions.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Purity Greater than 97% as determined by SDS-PAGE
Description The mature form of Cynomolgus (Macaca fascicularis) IL-13 (ABG75889.1) (Ser 21-Asn 132) was fused with a polyhistidine tag at the N-terminus
Host Species Cynomolgus
Usage Our products are for research use only. This product is not intended or approved for human, diagnostics or veterinary use
Storage Store recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
AA Sequence Ser 21-Asn 132
Product Background Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses and diseases. In addition, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody is more importantly implicated as a central mediator of immunoregulatory processes in various cell types.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Terminal His
Bioactivity 1. Measured by its binding ability in a functional ELISA. Immobilized cynomolgus IL-13 at 4 ug/ml (100 ul/well) can bind human IL13RA1 with a linear ranger of 0.156-2.5 ug/ml.2. Measured in a cell proliferation assay using TF1 human erythroleukemic cells (Kitamura, T. et al. (1989) J. Cell Physiol. 140 323.). The ED50 for this effect is typically 50-200 ng/mL.